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Computational Insight into Protein Tyrosine Phosphatase 1B Inhibition: A Case Study of the Combined Ligand- and Structure-Based Approach

Protein tyrosine phosphatase 1B (PTP1B) is an attractive target for treating cancer, obesity, and type 2 diabetes. In our work, the way of combined ligand- and structure-based approach was applied to analyze the characteristics of PTP1B enzyme and its interaction with competitive inhibitors. Firstly...

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Detalles Bibliográficos
Autores principales:	Zhang, Xiangyu, Jiang, Hailun, Li, Wei, Wang, Jian, Cheng, Maosheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758944/ https://www.ncbi.nlm.nih.gov/pubmed/29441120 http://dx.doi.org/10.1155/2017/4245613

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