Cargando…
Supplementation of Micronutrient Selenium in Metabolic Diseases: Its Role as an Antioxidant
Selenium is an essential mineral naturally found in soil, water, and some of the food. As an antioxidant, it is one of the necessary trace elements in human body and has been suggested as a dietary supplement for health benefit. Although the human body only needs a trace amount of selenium every day...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758946/ https://www.ncbi.nlm.nih.gov/pubmed/29441149 http://dx.doi.org/10.1155/2017/7478523 |
_version_ | 1783291098430439424 |
---|---|
author | Wang, Ning Tan, Hor-Yue Li, Sha Xu, Yu Guo, Wei Feng, Yibin |
author_facet | Wang, Ning Tan, Hor-Yue Li, Sha Xu, Yu Guo, Wei Feng, Yibin |
author_sort | Wang, Ning |
collection | PubMed |
description | Selenium is an essential mineral naturally found in soil, water, and some of the food. As an antioxidant, it is one of the necessary trace elements in human body and has been suggested as a dietary supplement for health benefit. Although the human body only needs a trace amount of selenium every day, plenty of recent studies have revealed that selenium is indispensable for maintaining normal functions of metabolism. In this study, we reviewed the antioxidant role of nutritional supplementation of selenium in the management of major chronic metabolic disorders, including hyperlipidaemia, hyperglycaemia, and hyperphenylalaninemia. Clinical significance of selenium deficiency in chronic metabolic diseases was elaborated, while clinical and experimental observations of dietary supplementation of selenium in treating chronic metabolic diseases, such as diabetes, arteriosclerosis, and phenylketonuria, were summarized. Toxicity and recommended dose of selenium were discussed. The mechanism of action was also proposed via inspecting the interaction of molecular networks and predicting target protein such as xanthine dehydrogenase in various diseases. Future direction in studying the role of selenium in metabolic disorders was also highlighted. In conclusion, highlighting the beneficial role of selenium in this review would advance our knowledge of the dietary management of chronic metabolic diseases. |
format | Online Article Text |
id | pubmed-5758946 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-57589462018-02-13 Supplementation of Micronutrient Selenium in Metabolic Diseases: Its Role as an Antioxidant Wang, Ning Tan, Hor-Yue Li, Sha Xu, Yu Guo, Wei Feng, Yibin Oxid Med Cell Longev Review Article Selenium is an essential mineral naturally found in soil, water, and some of the food. As an antioxidant, it is one of the necessary trace elements in human body and has been suggested as a dietary supplement for health benefit. Although the human body only needs a trace amount of selenium every day, plenty of recent studies have revealed that selenium is indispensable for maintaining normal functions of metabolism. In this study, we reviewed the antioxidant role of nutritional supplementation of selenium in the management of major chronic metabolic disorders, including hyperlipidaemia, hyperglycaemia, and hyperphenylalaninemia. Clinical significance of selenium deficiency in chronic metabolic diseases was elaborated, while clinical and experimental observations of dietary supplementation of selenium in treating chronic metabolic diseases, such as diabetes, arteriosclerosis, and phenylketonuria, were summarized. Toxicity and recommended dose of selenium were discussed. The mechanism of action was also proposed via inspecting the interaction of molecular networks and predicting target protein such as xanthine dehydrogenase in various diseases. Future direction in studying the role of selenium in metabolic disorders was also highlighted. In conclusion, highlighting the beneficial role of selenium in this review would advance our knowledge of the dietary management of chronic metabolic diseases. Hindawi 2017 2017-12-26 /pmc/articles/PMC5758946/ /pubmed/29441149 http://dx.doi.org/10.1155/2017/7478523 Text en Copyright © 2017 Ning Wang et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Wang, Ning Tan, Hor-Yue Li, Sha Xu, Yu Guo, Wei Feng, Yibin Supplementation of Micronutrient Selenium in Metabolic Diseases: Its Role as an Antioxidant |
title | Supplementation of Micronutrient Selenium in Metabolic Diseases: Its Role as an Antioxidant |
title_full | Supplementation of Micronutrient Selenium in Metabolic Diseases: Its Role as an Antioxidant |
title_fullStr | Supplementation of Micronutrient Selenium in Metabolic Diseases: Its Role as an Antioxidant |
title_full_unstemmed | Supplementation of Micronutrient Selenium in Metabolic Diseases: Its Role as an Antioxidant |
title_short | Supplementation of Micronutrient Selenium in Metabolic Diseases: Its Role as an Antioxidant |
title_sort | supplementation of micronutrient selenium in metabolic diseases: its role as an antioxidant |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758946/ https://www.ncbi.nlm.nih.gov/pubmed/29441149 http://dx.doi.org/10.1155/2017/7478523 |
work_keys_str_mv | AT wangning supplementationofmicronutrientseleniuminmetabolicdiseasesitsroleasanantioxidant AT tanhoryue supplementationofmicronutrientseleniuminmetabolicdiseasesitsroleasanantioxidant AT lisha supplementationofmicronutrientseleniuminmetabolicdiseasesitsroleasanantioxidant AT xuyu supplementationofmicronutrientseleniuminmetabolicdiseasesitsroleasanantioxidant AT guowei supplementationofmicronutrientseleniuminmetabolicdiseasesitsroleasanantioxidant AT fengyibin supplementationofmicronutrientseleniuminmetabolicdiseasesitsroleasanantioxidant |