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A Profile of Pediatric Solid Tumors: A Single Institution Experience in Kashmir

AIMS: The purpose of this retroprospective study was to study the epidemiological characteristics and outcomes of children with solid tumors at our institution. SUBJECTS AND METHODS: Three hundred and three pediatrics patients registered at Regional Cancer Centre (RCC), Sher-i-Kashmir Institute of M...

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Autores principales: Sharma, Namita, Ahmad, Ayesha, Bhat, Gull M, Aziz, Sheikh A, Lone, Mohammad Maqbool, Bhat, Nisar A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759067/
https://www.ncbi.nlm.nih.gov/pubmed/29333015
http://dx.doi.org/10.4103/ijmpo.ijmpo_95_16
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author Sharma, Namita
Ahmad, Ayesha
Bhat, Gull M
Aziz, Sheikh A
Lone, Mohammad Maqbool
Bhat, Nisar A
author_facet Sharma, Namita
Ahmad, Ayesha
Bhat, Gull M
Aziz, Sheikh A
Lone, Mohammad Maqbool
Bhat, Nisar A
author_sort Sharma, Namita
collection PubMed
description AIMS: The purpose of this retroprospective study was to study the epidemiological characteristics and outcomes of children with solid tumors at our institution. SUBJECTS AND METHODS: Three hundred and three pediatrics patients registered at Regional Cancer Centre (RCC), Sher-i-Kashmir Institute of Medical Sciences (SKIMS), Srinagar, Kashmir, between January 2008 and June 2014, were analyzed with regard to demographic status, presenting complaints, investigations, treatment, morbidity, and outcomes. Standard statistical methods were used for analysis. RESULTS: Among 19,880 patients registered at RCC, SKIMS from January 2008 till June 2014, 986 (4.9%) were of pediatric age group. Of these, 303 (30.7%) patients had pediatric solid tumors. The male-to-female ratio was 1.04, there were no infants (up to 27 days), 6% were infants and toddlers (28 days–23 months), 39% were children (2–11 years), and 55% were adolescents (12–19 years). There were 86% rural patients and 14% urban patients. Most common were central nervous system tumors (25.74%), followed by germ cell tumors (14.52%), primitive neuroectodermal tumor/Ewing sarcoma (13.86%), Wilms' tumor (8.9%), osteosarcoma (6.6%), rhabdomyosarcoma (5.6%), colorectal cancer (5.28%), neuroblastoma (4.9%), and retinoblastoma (2.6%). Outcomes: 33.9% patients went into remission, 35.64% were defaulters, 2.97% had stable disease, 2.31% had partial response, 20.79% expired, and 3.96% were still on treatment. Of all these patients, 5.28% had a relapse. CONCLUSIONS: Across the series, advanced stage of presentation, a high incidence of default and poor follow-up was seen. Multiple interrelated factors are responsible for the poorer outlook of childhood cancer in Kashmir.
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spelling pubmed-57590672018-01-12 A Profile of Pediatric Solid Tumors: A Single Institution Experience in Kashmir Sharma, Namita Ahmad, Ayesha Bhat, Gull M Aziz, Sheikh A Lone, Mohammad Maqbool Bhat, Nisar A Indian J Med Paediatr Oncol Original Article AIMS: The purpose of this retroprospective study was to study the epidemiological characteristics and outcomes of children with solid tumors at our institution. SUBJECTS AND METHODS: Three hundred and three pediatrics patients registered at Regional Cancer Centre (RCC), Sher-i-Kashmir Institute of Medical Sciences (SKIMS), Srinagar, Kashmir, between January 2008 and June 2014, were analyzed with regard to demographic status, presenting complaints, investigations, treatment, morbidity, and outcomes. Standard statistical methods were used for analysis. RESULTS: Among 19,880 patients registered at RCC, SKIMS from January 2008 till June 2014, 986 (4.9%) were of pediatric age group. Of these, 303 (30.7%) patients had pediatric solid tumors. The male-to-female ratio was 1.04, there were no infants (up to 27 days), 6% were infants and toddlers (28 days–23 months), 39% were children (2–11 years), and 55% were adolescents (12–19 years). There were 86% rural patients and 14% urban patients. Most common were central nervous system tumors (25.74%), followed by germ cell tumors (14.52%), primitive neuroectodermal tumor/Ewing sarcoma (13.86%), Wilms' tumor (8.9%), osteosarcoma (6.6%), rhabdomyosarcoma (5.6%), colorectal cancer (5.28%), neuroblastoma (4.9%), and retinoblastoma (2.6%). Outcomes: 33.9% patients went into remission, 35.64% were defaulters, 2.97% had stable disease, 2.31% had partial response, 20.79% expired, and 3.96% were still on treatment. Of all these patients, 5.28% had a relapse. CONCLUSIONS: Across the series, advanced stage of presentation, a high incidence of default and poor follow-up was seen. Multiple interrelated factors are responsible for the poorer outlook of childhood cancer in Kashmir. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5759067/ /pubmed/29333015 http://dx.doi.org/10.4103/ijmpo.ijmpo_95_16 Text en Copyright: © 2017 Indian Journal of Medical and Paediatric Oncology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Sharma, Namita
Ahmad, Ayesha
Bhat, Gull M
Aziz, Sheikh A
Lone, Mohammad Maqbool
Bhat, Nisar A
A Profile of Pediatric Solid Tumors: A Single Institution Experience in Kashmir
title A Profile of Pediatric Solid Tumors: A Single Institution Experience in Kashmir
title_full A Profile of Pediatric Solid Tumors: A Single Institution Experience in Kashmir
title_fullStr A Profile of Pediatric Solid Tumors: A Single Institution Experience in Kashmir
title_full_unstemmed A Profile of Pediatric Solid Tumors: A Single Institution Experience in Kashmir
title_short A Profile of Pediatric Solid Tumors: A Single Institution Experience in Kashmir
title_sort profile of pediatric solid tumors: a single institution experience in kashmir
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759067/
https://www.ncbi.nlm.nih.gov/pubmed/29333015
http://dx.doi.org/10.4103/ijmpo.ijmpo_95_16
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