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Flagellate Rash: An Unusual Complication of Bleomycin Therapy – A Case Report with Brief Review of Literature

Chemotherapy-induced skin rashes are common toxicities encountered which require careful assessment and evaluation as rashes could be a manifestation of primary malignancy itself and a variety of drugs used in combination further complicate the clinical scenario. Bleomycin is an anticancer antibioti...

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Autores principales: Agrawal, Chaturbhuj, Talwar, Vineet, Saini, Rajeev, Babu, Pradeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759081/
https://www.ncbi.nlm.nih.gov/pubmed/29333029
http://dx.doi.org/10.4103/ijmpo.ijmpo_147_16
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author Agrawal, Chaturbhuj
Talwar, Vineet
Saini, Rajeev
Babu, Pradeep
author_facet Agrawal, Chaturbhuj
Talwar, Vineet
Saini, Rajeev
Babu, Pradeep
author_sort Agrawal, Chaturbhuj
collection PubMed
description Chemotherapy-induced skin rashes are common toxicities encountered which require careful assessment and evaluation as rashes could be a manifestation of primary malignancy itself and a variety of drugs used in combination further complicate the clinical scenario. Bleomycin is an anticancer antibiotic derived from Streptomyces verticillus and has been commonly used in the treatment of Hodgkin's disease, germ cell tumors and for pleurodesis. There are various dermatological adverse effects of bleomycin which have been previously reported in literature including skin peeling, hyperkeratosis, nail bed changes, Raynaud's phenomenon, and palmoplantar desquamation. Bleomycin-induced skin rashes are seen infrequently now a day due to its declining use in clinical practice. We report here a 29-year-old male with Stage III germ cell tumor who developed widespread flagellate rash after receiving 3 cycles of bleomycin-based chemotherapy which responded to treatment with local steroids and omission of bleomycin from further chemotherapy cycles.
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spelling pubmed-57590812018-01-12 Flagellate Rash: An Unusual Complication of Bleomycin Therapy – A Case Report with Brief Review of Literature Agrawal, Chaturbhuj Talwar, Vineet Saini, Rajeev Babu, Pradeep Indian J Med Paediatr Oncol Case Report Chemotherapy-induced skin rashes are common toxicities encountered which require careful assessment and evaluation as rashes could be a manifestation of primary malignancy itself and a variety of drugs used in combination further complicate the clinical scenario. Bleomycin is an anticancer antibiotic derived from Streptomyces verticillus and has been commonly used in the treatment of Hodgkin's disease, germ cell tumors and for pleurodesis. There are various dermatological adverse effects of bleomycin which have been previously reported in literature including skin peeling, hyperkeratosis, nail bed changes, Raynaud's phenomenon, and palmoplantar desquamation. Bleomycin-induced skin rashes are seen infrequently now a day due to its declining use in clinical practice. We report here a 29-year-old male with Stage III germ cell tumor who developed widespread flagellate rash after receiving 3 cycles of bleomycin-based chemotherapy which responded to treatment with local steroids and omission of bleomycin from further chemotherapy cycles. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5759081/ /pubmed/29333029 http://dx.doi.org/10.4103/ijmpo.ijmpo_147_16 Text en Copyright: © 2017 Indian Journal of Medical and Paediatric Oncology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Agrawal, Chaturbhuj
Talwar, Vineet
Saini, Rajeev
Babu, Pradeep
Flagellate Rash: An Unusual Complication of Bleomycin Therapy – A Case Report with Brief Review of Literature
title Flagellate Rash: An Unusual Complication of Bleomycin Therapy – A Case Report with Brief Review of Literature
title_full Flagellate Rash: An Unusual Complication of Bleomycin Therapy – A Case Report with Brief Review of Literature
title_fullStr Flagellate Rash: An Unusual Complication of Bleomycin Therapy – A Case Report with Brief Review of Literature
title_full_unstemmed Flagellate Rash: An Unusual Complication of Bleomycin Therapy – A Case Report with Brief Review of Literature
title_short Flagellate Rash: An Unusual Complication of Bleomycin Therapy – A Case Report with Brief Review of Literature
title_sort flagellate rash: an unusual complication of bleomycin therapy – a case report with brief review of literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759081/
https://www.ncbi.nlm.nih.gov/pubmed/29333029
http://dx.doi.org/10.4103/ijmpo.ijmpo_147_16
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