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Severe thoracic trauma – still an independent predictor for death in multiple injured patients?

BACKGROUND: Over the past, the severe thoracic trauma has had decisive influence on the outcome of multiple injured patients. Today, new therapies (e.g. extracorporeal membrane oxygenation (ECMO), protective ventilation methods and new forms of patient positioning) are available and applied regularl...

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Autores principales: Grubmüller, Michael, Kerschbaum, Maximilian, Diepold, Eva, Angerpointner, Katharina, Nerlich, Michael, Ernstberger, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759165/
https://www.ncbi.nlm.nih.gov/pubmed/29310701
http://dx.doi.org/10.1186/s13049-017-0469-7
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author Grubmüller, Michael
Kerschbaum, Maximilian
Diepold, Eva
Angerpointner, Katharina
Nerlich, Michael
Ernstberger, Antonio
author_facet Grubmüller, Michael
Kerschbaum, Maximilian
Diepold, Eva
Angerpointner, Katharina
Nerlich, Michael
Ernstberger, Antonio
author_sort Grubmüller, Michael
collection PubMed
description BACKGROUND: Over the past, the severe thoracic trauma has had decisive influence on the outcome of multiple injured patients. Today, new therapies (e.g. extracorporeal membrane oxygenation (ECMO), protective ventilation methods and new forms of patient positioning) are available and applied regularly. What impact on the patient’s outcome does the thoracic trauma have today? METHODS: Prospective data collection of multiple injured patients in a level-I trauma center was performed between 2008 and 2014. Patients with an ISS ≥16 were included and divided into 2 groups: Severe thoracic trauma (STT: AIS(Thorax) ≥ 3) and mild thoracic trauma (MTT: AIS(Thorax) < 3). In addition to preclinical and trauma room care, detailed information about clinical course and outcome were assessed. RESULTS: In total, 529 patients (STT: n = 317; MTT: n = 212) met the in- and exclusion criteria. The mean Injury Severity Score (ISS) was significantly higher in patients of the STT group (STT: 33.5 vs. MTT: 24.7; p < 0.001), while the RISC II Score showed no significant differences (STT: 20.0 vs. MTT: 17.1; p = 0.241). Preclinical data revealed a higher intubation rate, more chest tube insertions and a higher use of catecholamines in the STT group (p < 0.05). Clinically, we found significant differences in the duration of invasive ventilation (STT: 7.3d vs. MTT: 5.4d; p = 0.001) and ICU stay (STT: 12.3d vs. MTT: 9.4d; p < 0.001). While the complication rate was higher for the STT group (sepsis (STT: 11.4% vs. MTT: 5.7%; p = 0.017); lung failure (STT: 23.7% vs. MTT: 12.3%; p = 0,001)), neither the non-adjusted lethality rate (STT: 13.2% vs. MTT: 13.7%; p = 0.493) nor the Standardized Mortality Ratio (SMR) showed significant differences (STT: 0.66 vs. MTT: 0.80; p = 0.397). The multivariate regressive analysis confirmed that severe thoracic trauma is not an independent risk factor for lethality in our patient cohort. CONCLUSION: Despite a higher injury severity, the extended need of emergency measures and a higher rate of complications in injured patients with severe blunt thoracic trauma, no influence on lethality can be proved. The reduction of the complication rate should be a goal for the next decades.
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spelling pubmed-57591652018-01-10 Severe thoracic trauma – still an independent predictor for death in multiple injured patients? Grubmüller, Michael Kerschbaum, Maximilian Diepold, Eva Angerpointner, Katharina Nerlich, Michael Ernstberger, Antonio Scand J Trauma Resusc Emerg Med Original Research BACKGROUND: Over the past, the severe thoracic trauma has had decisive influence on the outcome of multiple injured patients. Today, new therapies (e.g. extracorporeal membrane oxygenation (ECMO), protective ventilation methods and new forms of patient positioning) are available and applied regularly. What impact on the patient’s outcome does the thoracic trauma have today? METHODS: Prospective data collection of multiple injured patients in a level-I trauma center was performed between 2008 and 2014. Patients with an ISS ≥16 were included and divided into 2 groups: Severe thoracic trauma (STT: AIS(Thorax) ≥ 3) and mild thoracic trauma (MTT: AIS(Thorax) < 3). In addition to preclinical and trauma room care, detailed information about clinical course and outcome were assessed. RESULTS: In total, 529 patients (STT: n = 317; MTT: n = 212) met the in- and exclusion criteria. The mean Injury Severity Score (ISS) was significantly higher in patients of the STT group (STT: 33.5 vs. MTT: 24.7; p < 0.001), while the RISC II Score showed no significant differences (STT: 20.0 vs. MTT: 17.1; p = 0.241). Preclinical data revealed a higher intubation rate, more chest tube insertions and a higher use of catecholamines in the STT group (p < 0.05). Clinically, we found significant differences in the duration of invasive ventilation (STT: 7.3d vs. MTT: 5.4d; p = 0.001) and ICU stay (STT: 12.3d vs. MTT: 9.4d; p < 0.001). While the complication rate was higher for the STT group (sepsis (STT: 11.4% vs. MTT: 5.7%; p = 0.017); lung failure (STT: 23.7% vs. MTT: 12.3%; p = 0,001)), neither the non-adjusted lethality rate (STT: 13.2% vs. MTT: 13.7%; p = 0.493) nor the Standardized Mortality Ratio (SMR) showed significant differences (STT: 0.66 vs. MTT: 0.80; p = 0.397). The multivariate regressive analysis confirmed that severe thoracic trauma is not an independent risk factor for lethality in our patient cohort. CONCLUSION: Despite a higher injury severity, the extended need of emergency measures and a higher rate of complications in injured patients with severe blunt thoracic trauma, no influence on lethality can be proved. The reduction of the complication rate should be a goal for the next decades. BioMed Central 2018-01-08 /pmc/articles/PMC5759165/ /pubmed/29310701 http://dx.doi.org/10.1186/s13049-017-0469-7 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Original Research
Grubmüller, Michael
Kerschbaum, Maximilian
Diepold, Eva
Angerpointner, Katharina
Nerlich, Michael
Ernstberger, Antonio
Severe thoracic trauma – still an independent predictor for death in multiple injured patients?
title Severe thoracic trauma – still an independent predictor for death in multiple injured patients?
title_full Severe thoracic trauma – still an independent predictor for death in multiple injured patients?
title_fullStr Severe thoracic trauma – still an independent predictor for death in multiple injured patients?
title_full_unstemmed Severe thoracic trauma – still an independent predictor for death in multiple injured patients?
title_short Severe thoracic trauma – still an independent predictor for death in multiple injured patients?
title_sort severe thoracic trauma – still an independent predictor for death in multiple injured patients?
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759165/
https://www.ncbi.nlm.nih.gov/pubmed/29310701
http://dx.doi.org/10.1186/s13049-017-0469-7
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