A novel Notch1 missense mutation (C1133Y) in the Abruptex domain exhibits enhanced proliferation and invasion in oral squamous cell carcinoma

BACKGROUND: Notch1 has been regarded as a fundamental regulator in tissue differentiation and stem cell properties. Recently, Notch1 mutations have been reported intensively both in solid tumors and in hematopoietic malignancies. However, little is known about the biological effect and the clinical...

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Detalles Bibliográficos
Autores principales: Zheng, Yang, Wang, Zhao, Ding, Xu, Zhang, Wei, Li, Gang, Liu, Laikui, Wu, Heming, Gu, Wenyi, Wu, Yunong, Song, Xiaomeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759178/
https://www.ncbi.nlm.nih.gov/pubmed/29321718
http://dx.doi.org/10.1186/s12935-017-0496-5

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