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A cross-sectional study of the filarial and Leishmania co-endemicity in two ecologically distinct settings in Mali

BACKGROUND: Filariasis and leishmaniasis are two neglected tropical diseases in Mali. Due to distribution and associated clinical features, both diseases are of concern to public health. The goal of this study was to determine the prevalence of co-infection with filarial (Wuchereria bancrofti and Ma...

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Autores principales: Sangare, Moussa Brema, Coulibaly, Yaya Ibrahim, Coulibaly, Siaka Yamoussa, Coulibaly, Michel Emmanuel, Traore, Bourama, Dicko, Ilo, Sissoko, Ibrahim Moussa, Samake, Sibiry, Traore, Sekou Fantamady, Nutman, Thomas Bruce, Valenzuela, Jesus Gilberto, Faye, Ousmane, Kamhawi, Shaden, Oliveira, Fabiano, Semnani, Roshanak Tolouei, Doumbia, Seydou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759231/
https://www.ncbi.nlm.nih.gov/pubmed/29310700
http://dx.doi.org/10.1186/s13071-017-2531-8
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author Sangare, Moussa Brema
Coulibaly, Yaya Ibrahim
Coulibaly, Siaka Yamoussa
Coulibaly, Michel Emmanuel
Traore, Bourama
Dicko, Ilo
Sissoko, Ibrahim Moussa
Samake, Sibiry
Traore, Sekou Fantamady
Nutman, Thomas Bruce
Valenzuela, Jesus Gilberto
Faye, Ousmane
Kamhawi, Shaden
Oliveira, Fabiano
Semnani, Roshanak Tolouei
Doumbia, Seydou
author_facet Sangare, Moussa Brema
Coulibaly, Yaya Ibrahim
Coulibaly, Siaka Yamoussa
Coulibaly, Michel Emmanuel
Traore, Bourama
Dicko, Ilo
Sissoko, Ibrahim Moussa
Samake, Sibiry
Traore, Sekou Fantamady
Nutman, Thomas Bruce
Valenzuela, Jesus Gilberto
Faye, Ousmane
Kamhawi, Shaden
Oliveira, Fabiano
Semnani, Roshanak Tolouei
Doumbia, Seydou
author_sort Sangare, Moussa Brema
collection PubMed
description BACKGROUND: Filariasis and leishmaniasis are two neglected tropical diseases in Mali. Due to distribution and associated clinical features, both diseases are of concern to public health. The goal of this study was to determine the prevalence of co-infection with filarial (Wuchereria bancrofti and Mansonella perstans) and Leishmania major parasites in two ecologically distinct areas of Mali, the Kolokani district (villages of Tieneguebougou and Bougoudiana) in North Sudan Savanna area, and the district of Kolondieba (village of Boundioba) in the South Sudan Savanna area. METHODS: The prevalence of co-infection (filarial and Leishmania) was measured based on (i) Mansonella perstans microfilaremia count and/or filariasis immunochromatographic test (ICT) for Wuchereria bancrofti-specific circulating antigen, and (ii) the prevalence of delayed type hypersensitivity (DTH) responses to Leishmania measured by leishmanin skin test (LST). RESULTS: In this study, a total of 930 volunteers between the age of 18 and 65 were included from the two endemic areas of Kolokani and Kolondieba. In general, in both areas, filarial infection was more prevalent than Leishmania infection with an overall prevalence of 15.27% (142/930) including 8.7% (81/930) for Mansonella perstans and 8% (74/930) for Wuchereria bancrofti-specific circulating antigen. The prevalence of Leishmania major infection was 7.7% (72/930) and was significantly higher in Tieneguebougou and Bougoudiana (15.05%; 64/425) than in Boundioba (2.04%; 8/505) (χ(2) = 58.66, P < 0.0001). Among the filarial infected population, nearly 10% (14/142) were also positive for Leishmania with an overall prevalence of co-infection of 1.50% (14/930) varying from 2.82% (12/425) in Tieneguebougou and Bougoudiana to 0.39% (2/505) in Boundioba (P = 0.0048). CONCLUSION: This study established the existence of co-endemicity of filarial and Leishmania infections in specific regions of Mali. Since both filarial and Leishmania infections are vector-borne with mosquitoes and sand flies as respective vectors, an integrated vector control approach should be considered in co-endemic areas. The effect of potential interaction between filarial and Leishmania parasites on the disease outcomes may be further studied.
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spelling pubmed-57592312018-01-10 A cross-sectional study of the filarial and Leishmania co-endemicity in two ecologically distinct settings in Mali Sangare, Moussa Brema Coulibaly, Yaya Ibrahim Coulibaly, Siaka Yamoussa Coulibaly, Michel Emmanuel Traore, Bourama Dicko, Ilo Sissoko, Ibrahim Moussa Samake, Sibiry Traore, Sekou Fantamady Nutman, Thomas Bruce Valenzuela, Jesus Gilberto Faye, Ousmane Kamhawi, Shaden Oliveira, Fabiano Semnani, Roshanak Tolouei Doumbia, Seydou Parasit Vectors Research BACKGROUND: Filariasis and leishmaniasis are two neglected tropical diseases in Mali. Due to distribution and associated clinical features, both diseases are of concern to public health. The goal of this study was to determine the prevalence of co-infection with filarial (Wuchereria bancrofti and Mansonella perstans) and Leishmania major parasites in two ecologically distinct areas of Mali, the Kolokani district (villages of Tieneguebougou and Bougoudiana) in North Sudan Savanna area, and the district of Kolondieba (village of Boundioba) in the South Sudan Savanna area. METHODS: The prevalence of co-infection (filarial and Leishmania) was measured based on (i) Mansonella perstans microfilaremia count and/or filariasis immunochromatographic test (ICT) for Wuchereria bancrofti-specific circulating antigen, and (ii) the prevalence of delayed type hypersensitivity (DTH) responses to Leishmania measured by leishmanin skin test (LST). RESULTS: In this study, a total of 930 volunteers between the age of 18 and 65 were included from the two endemic areas of Kolokani and Kolondieba. In general, in both areas, filarial infection was more prevalent than Leishmania infection with an overall prevalence of 15.27% (142/930) including 8.7% (81/930) for Mansonella perstans and 8% (74/930) for Wuchereria bancrofti-specific circulating antigen. The prevalence of Leishmania major infection was 7.7% (72/930) and was significantly higher in Tieneguebougou and Bougoudiana (15.05%; 64/425) than in Boundioba (2.04%; 8/505) (χ(2) = 58.66, P < 0.0001). Among the filarial infected population, nearly 10% (14/142) were also positive for Leishmania with an overall prevalence of co-infection of 1.50% (14/930) varying from 2.82% (12/425) in Tieneguebougou and Bougoudiana to 0.39% (2/505) in Boundioba (P = 0.0048). CONCLUSION: This study established the existence of co-endemicity of filarial and Leishmania infections in specific regions of Mali. Since both filarial and Leishmania infections are vector-borne with mosquitoes and sand flies as respective vectors, an integrated vector control approach should be considered in co-endemic areas. The effect of potential interaction between filarial and Leishmania parasites on the disease outcomes may be further studied. BioMed Central 2018-01-08 /pmc/articles/PMC5759231/ /pubmed/29310700 http://dx.doi.org/10.1186/s13071-017-2531-8 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Sangare, Moussa Brema
Coulibaly, Yaya Ibrahim
Coulibaly, Siaka Yamoussa
Coulibaly, Michel Emmanuel
Traore, Bourama
Dicko, Ilo
Sissoko, Ibrahim Moussa
Samake, Sibiry
Traore, Sekou Fantamady
Nutman, Thomas Bruce
Valenzuela, Jesus Gilberto
Faye, Ousmane
Kamhawi, Shaden
Oliveira, Fabiano
Semnani, Roshanak Tolouei
Doumbia, Seydou
A cross-sectional study of the filarial and Leishmania co-endemicity in two ecologically distinct settings in Mali
title A cross-sectional study of the filarial and Leishmania co-endemicity in two ecologically distinct settings in Mali
title_full A cross-sectional study of the filarial and Leishmania co-endemicity in two ecologically distinct settings in Mali
title_fullStr A cross-sectional study of the filarial and Leishmania co-endemicity in two ecologically distinct settings in Mali
title_full_unstemmed A cross-sectional study of the filarial and Leishmania co-endemicity in two ecologically distinct settings in Mali
title_short A cross-sectional study of the filarial and Leishmania co-endemicity in two ecologically distinct settings in Mali
title_sort cross-sectional study of the filarial and leishmania co-endemicity in two ecologically distinct settings in mali
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759231/
https://www.ncbi.nlm.nih.gov/pubmed/29310700
http://dx.doi.org/10.1186/s13071-017-2531-8
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