Cargando…

134: THE EFFECTIVENESS OF CXL IN THE TREATMENT OF KERATOCONUS

BACKGROUND AND AIMS: Keratoconus is characterized by corneal ectasia and irregular astigmatism, which can lead to diminished vision and corneal scarring. Keratoconus is a condition that causes corneal ectasia and reduced vision in young adults. A proportion of these patients have progressive disease...

Descripción completa

Detalles Bibliográficos
Autores principales: Esmaeilnezhad, Mahdieh, Seyyedrasooli, Alehe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759687/
http://dx.doi.org/10.1136/bmjopen-2016-015415.134
_version_ 1783291257181700096
author Esmaeilnezhad, Mahdieh
Seyyedrasooli, Alehe
author_facet Esmaeilnezhad, Mahdieh
Seyyedrasooli, Alehe
author_sort Esmaeilnezhad, Mahdieh
collection PubMed
description BACKGROUND AND AIMS: Keratoconus is characterized by corneal ectasia and irregular astigmatism, which can lead to diminished vision and corneal scarring. Keratoconus is a condition that causes corneal ectasia and reduced vision in young adults. A proportion of these patients have progressive disease requiring corneal transplantation. METHODS: The databases searched included OVID MEDLINE, MEDLINE IN-Process and other Non-Indexed Citations such as EMBASE with keyword Keratoconus and Corneal cross-linking. RESULTS: Rocha KM and et al. (2014) funded that Epithelial thickness standard deviations were significantly lower 3 months after CXL, compared to ranges before CXL in both the vertical and horizontal meridians for keratoconus and ectasia (P=0.048). No significant differences were found between epithelial remodeling in keratoconus and corneal ectasia (P=0.98). No significant or consistent stromal changes were found for either group. Cınar and et al. (2013) funded that Flat keratometry, steep keratometry, mean keratometry and maximum keratometry were significantly reduced at the 6th month after CXL (p=0.025, p<0.001, p=0.004 and p=0.03, respectively). Thinnest corneal thickness (TCT) and endothelial cell density (ECD) were not changed significantly the 6th month after CXL (p=0.135 and p=0.082, respectively). Brooks NO and et al. (2012) funded that After CXL, patients noted subjective improvement in visual symptoms, specifically night driving, difficulty reading, diplopia, glare, halo, starbursts, and foreign-body sensation. CONCLUSION: Significantly fewer corneal transplants were performed for treating keratoconus following the nationwide introduction of CXL. This reduction suggests that corneal cross-linking can significantly reduce the need for corneal transplantation. CXL represents a new treatment that uniquely allows the halt of progression of keratoconus, thus preventing visual loss and the need for surgical intervention.
format Online
Article
Text
id pubmed-5759687
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher BMJ Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-57596872018-02-12 134: THE EFFECTIVENESS OF CXL IN THE TREATMENT OF KERATOCONUS Esmaeilnezhad, Mahdieh Seyyedrasooli, Alehe BMJ Open Abstracts from the 5th International Society for Evidence-Based Healthcare Congress, Kish Island, Ira BACKGROUND AND AIMS: Keratoconus is characterized by corneal ectasia and irregular astigmatism, which can lead to diminished vision and corneal scarring. Keratoconus is a condition that causes corneal ectasia and reduced vision in young adults. A proportion of these patients have progressive disease requiring corneal transplantation. METHODS: The databases searched included OVID MEDLINE, MEDLINE IN-Process and other Non-Indexed Citations such as EMBASE with keyword Keratoconus and Corneal cross-linking. RESULTS: Rocha KM and et al. (2014) funded that Epithelial thickness standard deviations were significantly lower 3 months after CXL, compared to ranges before CXL in both the vertical and horizontal meridians for keratoconus and ectasia (P=0.048). No significant differences were found between epithelial remodeling in keratoconus and corneal ectasia (P=0.98). No significant or consistent stromal changes were found for either group. Cınar and et al. (2013) funded that Flat keratometry, steep keratometry, mean keratometry and maximum keratometry were significantly reduced at the 6th month after CXL (p=0.025, p<0.001, p=0.004 and p=0.03, respectively). Thinnest corneal thickness (TCT) and endothelial cell density (ECD) were not changed significantly the 6th month after CXL (p=0.135 and p=0.082, respectively). Brooks NO and et al. (2012) funded that After CXL, patients noted subjective improvement in visual symptoms, specifically night driving, difficulty reading, diplopia, glare, halo, starbursts, and foreign-body sensation. CONCLUSION: Significantly fewer corneal transplants were performed for treating keratoconus following the nationwide introduction of CXL. This reduction suggests that corneal cross-linking can significantly reduce the need for corneal transplantation. CXL represents a new treatment that uniquely allows the halt of progression of keratoconus, thus preventing visual loss and the need for surgical intervention. BMJ Publishing Group 2017-02-08 /pmc/articles/PMC5759687/ http://dx.doi.org/10.1136/bmjopen-2016-015415.134 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Abstracts from the 5th International Society for Evidence-Based Healthcare Congress, Kish Island, Ira
Esmaeilnezhad, Mahdieh
Seyyedrasooli, Alehe
134: THE EFFECTIVENESS OF CXL IN THE TREATMENT OF KERATOCONUS
title 134: THE EFFECTIVENESS OF CXL IN THE TREATMENT OF KERATOCONUS
title_full 134: THE EFFECTIVENESS OF CXL IN THE TREATMENT OF KERATOCONUS
title_fullStr 134: THE EFFECTIVENESS OF CXL IN THE TREATMENT OF KERATOCONUS
title_full_unstemmed 134: THE EFFECTIVENESS OF CXL IN THE TREATMENT OF KERATOCONUS
title_short 134: THE EFFECTIVENESS OF CXL IN THE TREATMENT OF KERATOCONUS
title_sort 134: the effectiveness of cxl in the treatment of keratoconus
topic Abstracts from the 5th International Society for Evidence-Based Healthcare Congress, Kish Island, Ira
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759687/
http://dx.doi.org/10.1136/bmjopen-2016-015415.134
work_keys_str_mv AT esmaeilnezhadmahdieh 134theeffectivenessofcxlinthetreatmentofkeratoconus
AT seyyedrasoolialehe 134theeffectivenessofcxlinthetreatmentofkeratoconus