RNA-guided single/double gene repressions in Corynebacterium glutamicum using an efficient CRISPR interference and its application to industrial strain

BACKGROUND: The construction of microbial cell factories requires cost-effective and rapid strain development through metabolic engineering. Recently, RNA-guided CRISPR technologies have been developed for metabolic engineering of industrially-relevant host. RESULTS: To demonstrate the application o...

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Detalles Bibliográficos
Autores principales: Park, Jaehyun, Shin, Hyojung, Lee, Sun-Mi, Um, Youngsoon, Woo, Han Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759794/
https://www.ncbi.nlm.nih.gov/pubmed/29316926
http://dx.doi.org/10.1186/s12934-017-0843-1

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