Nitric oxide induced by Indian ginseng root extract inhibits Infectious Bursal Disease virus in chicken embryo fibroblasts in vitro

Infectious Bursal Disease is a severe viral disease of chicken responsible for serious economic losses to poultry farmers. The causative agent, Infectious Bursal Disease virus, is inhibited by nitric oxide. Root extract of the Indian ginseng, Withania somnifera, inhibits Infectious Bursal Disease vi...

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Autores principales: Ganguly, Bhaskar, Umapathi, Vijaypillai, Rastogi, Sunil Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759882/
https://www.ncbi.nlm.nih.gov/pubmed/29340165
http://dx.doi.org/10.1186/s40781-017-0156-2
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author Ganguly, Bhaskar
Umapathi, Vijaypillai
Rastogi, Sunil Kumar
author_facet Ganguly, Bhaskar
Umapathi, Vijaypillai
Rastogi, Sunil Kumar
author_sort Ganguly, Bhaskar
collection PubMed
description Infectious Bursal Disease is a severe viral disease of chicken responsible for serious economic losses to poultry farmers. The causative agent, Infectious Bursal Disease virus, is inhibited by nitric oxide. Root extract of the Indian ginseng, Withania somnifera, inhibits Infectious Bursal Disease virus in vitro. Also, Withania somnifera root extract is known to induce nitric oxide production in vitro. Therefore, the present study was undertaken to determine if the inhibitory activity of Withania somnifera against Infectious Bursal Disease virus was based on the production of nitric oxide. We show that besides other mechanisms, the inhibition of Infectious Bursal Disease virus by Withania somnifera involves the production of nitric oxide. Our results also highlight the paradoxical role of nitric oxide in the pathogenesis of Infectious Bursal Disease.
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spelling pubmed-57598822018-01-16 Nitric oxide induced by Indian ginseng root extract inhibits Infectious Bursal Disease virus in chicken embryo fibroblasts in vitro Ganguly, Bhaskar Umapathi, Vijaypillai Rastogi, Sunil Kumar J Anim Sci Technol Short Report Infectious Bursal Disease is a severe viral disease of chicken responsible for serious economic losses to poultry farmers. The causative agent, Infectious Bursal Disease virus, is inhibited by nitric oxide. Root extract of the Indian ginseng, Withania somnifera, inhibits Infectious Bursal Disease virus in vitro. Also, Withania somnifera root extract is known to induce nitric oxide production in vitro. Therefore, the present study was undertaken to determine if the inhibitory activity of Withania somnifera against Infectious Bursal Disease virus was based on the production of nitric oxide. We show that besides other mechanisms, the inhibition of Infectious Bursal Disease virus by Withania somnifera involves the production of nitric oxide. Our results also highlight the paradoxical role of nitric oxide in the pathogenesis of Infectious Bursal Disease. BioMed Central 2018-01-08 /pmc/articles/PMC5759882/ /pubmed/29340165 http://dx.doi.org/10.1186/s40781-017-0156-2 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Report
Ganguly, Bhaskar
Umapathi, Vijaypillai
Rastogi, Sunil Kumar
Nitric oxide induced by Indian ginseng root extract inhibits Infectious Bursal Disease virus in chicken embryo fibroblasts in vitro
title Nitric oxide induced by Indian ginseng root extract inhibits Infectious Bursal Disease virus in chicken embryo fibroblasts in vitro
title_full Nitric oxide induced by Indian ginseng root extract inhibits Infectious Bursal Disease virus in chicken embryo fibroblasts in vitro
title_fullStr Nitric oxide induced by Indian ginseng root extract inhibits Infectious Bursal Disease virus in chicken embryo fibroblasts in vitro
title_full_unstemmed Nitric oxide induced by Indian ginseng root extract inhibits Infectious Bursal Disease virus in chicken embryo fibroblasts in vitro
title_short Nitric oxide induced by Indian ginseng root extract inhibits Infectious Bursal Disease virus in chicken embryo fibroblasts in vitro
title_sort nitric oxide induced by indian ginseng root extract inhibits infectious bursal disease virus in chicken embryo fibroblasts in vitro
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759882/
https://www.ncbi.nlm.nih.gov/pubmed/29340165
http://dx.doi.org/10.1186/s40781-017-0156-2
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AT rastogisunilkumar nitricoxideinducedbyindianginsengrootextractinhibitsinfectiousbursaldiseasevirusinchickenembryofibroblastsinvitro

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