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Chemical biology of genomic DNA: minimizing PCR bias†

The exquisite selectivity of chemical reactions enables the study of rare DNA bases. However, chemical modification of the genome can affect downstream analysis. We report a PCR bias caused by such modification, and exemplify a solution with the synthesis and characterization of a cleavable aldehyde...

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Detalles Bibliográficos
Autores principales:	McInroy, Gordon R., Raiber, Eun-Ang, Balasubramanian, Shankar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759930/ https://www.ncbi.nlm.nih.gov/pubmed/25178041 http://dx.doi.org/10.1039/c4cc05107f

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