The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage

RNA-DNA hybrids are naturally occurring obstacles that must be overcome by the DNA replication machinery. In the absence of RNase H enzymes, RNA-DNA hybrids accumulate, resulting in replication stress, DNA damage and compromised genomic integrity. We demonstrate that Mph1, the yeast homolog of Fanco...

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Detalles Bibliográficos
Autores principales: Lafuente-Barquero, Juan, Luke-Glaser, Sarah, Graf, Marco, Silva, Sonia, Gómez-González, Belén, Lockhart, Arianna, Lisby, Michael, Aguilera, Andrés, Luke, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760084/
https://www.ncbi.nlm.nih.gov/pubmed/29281624
http://dx.doi.org/10.1371/journal.pgen.1007136

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