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Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel

The Gloeobacter violaceus ligand-gated ion channel (GLIC) has been extensively studied by X-ray crystallography and other biophysical techniques. This provided key insights into the general gating mechanism of pentameric ligand-gated ion channel (pLGIC) signal transduction. However, the GLIC is acti...

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Detalles Bibliográficos
Autores principales:	Nemecz, Ákos, Hu, Haidai, Fourati, Zaineb, Van Renterghem, Catherine, Delarue, Marc, Corringer, Pierre-Jean
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760087/ https://www.ncbi.nlm.nih.gov/pubmed/29281623 http://dx.doi.org/10.1371/journal.pbio.2004470

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