The translesion DNA polymerases Pol ζ and Rev1 are activated independently of PCNA ubiquitination upon UV radiation in mutants of DNA polymerase δ

Replicative DNA polymerases cannot insert efficiently nucleotides at sites of base lesions. This function is taken over by specialized translesion DNA synthesis (TLS) polymerases to allow DNA replication completion in the presence of DNA damage. In eukaryotes, Rad6- and Rad18-mediated PCNA ubiquitin...

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Detalles Bibliográficos
Autores principales: Tellier-Lebegue, Carine, Dizet, Eléa, Ma, Emilie, Veaute, Xavier, Coïc, Eric, Charbonnier, Jean-Baptiste, Maloisel, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760103/
https://www.ncbi.nlm.nih.gov/pubmed/29281621
http://dx.doi.org/10.1371/journal.pgen.1007119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760103/
https://www.ncbi.nlm.nih.gov/pubmed/29281621
http://dx.doi.org/10.1371/journal.pgen.1007119

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