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Relationship between Contrast Enhancement of the Perivascular Space in the Basal Ganglia and Endolymphatic Volume Ratio
PURPOSE: We routinely obtain the endolymphatic hydrops (EH) image using heavily T(2)-weighted three dimensional-fluid attenuated inversion recovery (hT(2)w-3D-FLAIR) imaging at 4 hours after intravenous administration of a single-dose of gadolinium-based contrast media (IV-SD-GBCM). While repeating...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Japanese Society for Magnetic Resonance in Medicine
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760235/ https://www.ncbi.nlm.nih.gov/pubmed/28592709 http://dx.doi.org/10.2463/mrms.mp.2017-0001 |
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author | Ohashi, Toshio Naganawa, Shinji Katagiri, Toshio Kuno, Kayao |
author_facet | Ohashi, Toshio Naganawa, Shinji Katagiri, Toshio Kuno, Kayao |
author_sort | Ohashi, Toshio |
collection | PubMed |
description | PURPOSE: We routinely obtain the endolymphatic hydrops (EH) image using heavily T(2)-weighted three dimensional-fluid attenuated inversion recovery (hT(2)w-3D-FLAIR) imaging at 4 hours after intravenous administration of a single-dose of gadolinium-based contrast media (IV-SD-GBCM). While repeating the examination, we speculated that the contrast enhancement of the perivascular space (PVS) in the basal ganglia might be related to the degree of EH. Therefore, the purpose of this study was to investigate the relationship between the endolymphatic volume ratio (%EL(volume)) and the signal intensity of the PVS (SI-PVS). MATERIALS AND METHODS: In 20 patients with a suspicion of EH, a heavily T(2)-weighted 3D-turbo spin echo sequence for MR cisternography (MRC) and an hT(2)w-3D-FLAIR as a positive perilymph image (PPI) were obtained at 4 hours after IV-SD-GBCM. The %EL(volume) of the cochlea and the vestibule were measured on the previously reported HYDROPS2-Mi2 image. The PVS in the basal ganglia was segmented on MRC using a region-growing method. The PVS regions were copied and pasted onto the PPI, and the SI-PVS was measured. The larger value of the right and the left ears was employed as the %EL(volume), and the weighted average of both sides was employed as the SI-PVS. The correlation between the %EL(volume) and the SI-PVS was evaluated. RESULT: There was a strong negative linear correlation between the %EL(volume) of the cochlea and the SI-PVS (r = −0.743, P < 0.001); however, there was no significant correlation between the %EL(volume) of the vestibule and the SI-PVS (r = −0.267, P = 0.256). CONCLUSION: There was a strong negative correlation between the cochlear %EL(volume) and the SI-PVS. Contrast enhancement of PVS might be a biomarker of EH. |
format | Online Article Text |
id | pubmed-5760235 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Japanese Society for Magnetic Resonance in Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-57602352018-01-19 Relationship between Contrast Enhancement of the Perivascular Space in the Basal Ganglia and Endolymphatic Volume Ratio Ohashi, Toshio Naganawa, Shinji Katagiri, Toshio Kuno, Kayao Magn Reson Med Sci Major Paper PURPOSE: We routinely obtain the endolymphatic hydrops (EH) image using heavily T(2)-weighted three dimensional-fluid attenuated inversion recovery (hT(2)w-3D-FLAIR) imaging at 4 hours after intravenous administration of a single-dose of gadolinium-based contrast media (IV-SD-GBCM). While repeating the examination, we speculated that the contrast enhancement of the perivascular space (PVS) in the basal ganglia might be related to the degree of EH. Therefore, the purpose of this study was to investigate the relationship between the endolymphatic volume ratio (%EL(volume)) and the signal intensity of the PVS (SI-PVS). MATERIALS AND METHODS: In 20 patients with a suspicion of EH, a heavily T(2)-weighted 3D-turbo spin echo sequence for MR cisternography (MRC) and an hT(2)w-3D-FLAIR as a positive perilymph image (PPI) were obtained at 4 hours after IV-SD-GBCM. The %EL(volume) of the cochlea and the vestibule were measured on the previously reported HYDROPS2-Mi2 image. The PVS in the basal ganglia was segmented on MRC using a region-growing method. The PVS regions were copied and pasted onto the PPI, and the SI-PVS was measured. The larger value of the right and the left ears was employed as the %EL(volume), and the weighted average of both sides was employed as the SI-PVS. The correlation between the %EL(volume) and the SI-PVS was evaluated. RESULT: There was a strong negative linear correlation between the %EL(volume) of the cochlea and the SI-PVS (r = −0.743, P < 0.001); however, there was no significant correlation between the %EL(volume) of the vestibule and the SI-PVS (r = −0.267, P = 0.256). CONCLUSION: There was a strong negative correlation between the cochlear %EL(volume) and the SI-PVS. Contrast enhancement of PVS might be a biomarker of EH. Japanese Society for Magnetic Resonance in Medicine 2017-06-08 /pmc/articles/PMC5760235/ /pubmed/28592709 http://dx.doi.org/10.2463/mrms.mp.2017-0001 Text en © 2017 Japanese Society for Magnetic Resonance in Medicine This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/ |
spellingShingle | Major Paper Ohashi, Toshio Naganawa, Shinji Katagiri, Toshio Kuno, Kayao Relationship between Contrast Enhancement of the Perivascular Space in the Basal Ganglia and Endolymphatic Volume Ratio |
title | Relationship between Contrast Enhancement of the Perivascular Space in the Basal Ganglia and Endolymphatic Volume Ratio |
title_full | Relationship between Contrast Enhancement of the Perivascular Space in the Basal Ganglia and Endolymphatic Volume Ratio |
title_fullStr | Relationship between Contrast Enhancement of the Perivascular Space in the Basal Ganglia and Endolymphatic Volume Ratio |
title_full_unstemmed | Relationship between Contrast Enhancement of the Perivascular Space in the Basal Ganglia and Endolymphatic Volume Ratio |
title_short | Relationship between Contrast Enhancement of the Perivascular Space in the Basal Ganglia and Endolymphatic Volume Ratio |
title_sort | relationship between contrast enhancement of the perivascular space in the basal ganglia and endolymphatic volume ratio |
topic | Major Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760235/ https://www.ncbi.nlm.nih.gov/pubmed/28592709 http://dx.doi.org/10.2463/mrms.mp.2017-0001 |
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