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B(1) Power Optimization for Chemical Exchange Saturation Transfer Imaging: A Phantom Study Using Egg White for Amide Proton Transfer Imaging Applications in the Human Brain

The chemical exchange saturation transfer (CEST) effect on an egg white (EW) suspension was investigated for optimization of magnetization transfer (MT) power (B(1,rms)) and pH dependency with the addition of lactic acid. Applying a higher MT pulse, B(1,rms), Z-spectrum shows higher asymmetry and th...

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Autores principales: Kanazawa, Yuki, Fushimi, Yasutaka, Sakashita, Naotaka, Okada, Tomohisa, Arakawa, Yoshiki, Miyazaki, Mitsue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society for Magnetic Resonance in Medicine 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760238/
https://www.ncbi.nlm.nih.gov/pubmed/28566586
http://dx.doi.org/10.2463/mrms.tn.2016-0069
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author Kanazawa, Yuki
Fushimi, Yasutaka
Sakashita, Naotaka
Okada, Tomohisa
Arakawa, Yoshiki
Miyazaki, Mitsue
author_facet Kanazawa, Yuki
Fushimi, Yasutaka
Sakashita, Naotaka
Okada, Tomohisa
Arakawa, Yoshiki
Miyazaki, Mitsue
author_sort Kanazawa, Yuki
collection PubMed
description The chemical exchange saturation transfer (CEST) effect on an egg white (EW) suspension was investigated for optimization of magnetization transfer (MT) power (B(1,rms)) and pH dependency with the addition of lactic acid. Applying a higher MT pulse, B(1,rms), Z-spectrum shows higher asymmetry and the magnetisation transfer ratio (MTR)(asym) signal increases to around 1–3.5 ppm, indicating a higher CEST effect. Amide proton transfer (APT) at 3.5 ppm shows a signal elevation in MTR(asym) with the application of higher B(1,rms) power and high pH. In addition, the hydroxyl proton signal in MTR(asym) increases as pH is reduced by lactic acid. In Z-spectrum of B(1,rms) at 1.0 μT and 2.0 μT, the dependence on CEST effect of amide proton and hydroxyl proton could be observed by using an EW suspension phantom. The CEST MT power was optimized on the EW suspension phantom with pH dependency and further confirmed on volunteers. In addition, APT imaging at 3.5 ppm using B(1,rms) at 1.0 μT performed on two human brains with different pathophysiological conditions indicated appropriate ATP effect.
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spelling pubmed-57602382018-01-19 B(1) Power Optimization for Chemical Exchange Saturation Transfer Imaging: A Phantom Study Using Egg White for Amide Proton Transfer Imaging Applications in the Human Brain Kanazawa, Yuki Fushimi, Yasutaka Sakashita, Naotaka Okada, Tomohisa Arakawa, Yoshiki Miyazaki, Mitsue Magn Reson Med Sci Technical Note The chemical exchange saturation transfer (CEST) effect on an egg white (EW) suspension was investigated for optimization of magnetization transfer (MT) power (B(1,rms)) and pH dependency with the addition of lactic acid. Applying a higher MT pulse, B(1,rms), Z-spectrum shows higher asymmetry and the magnetisation transfer ratio (MTR)(asym) signal increases to around 1–3.5 ppm, indicating a higher CEST effect. Amide proton transfer (APT) at 3.5 ppm shows a signal elevation in MTR(asym) with the application of higher B(1,rms) power and high pH. In addition, the hydroxyl proton signal in MTR(asym) increases as pH is reduced by lactic acid. In Z-spectrum of B(1,rms) at 1.0 μT and 2.0 μT, the dependence on CEST effect of amide proton and hydroxyl proton could be observed by using an EW suspension phantom. The CEST MT power was optimized on the EW suspension phantom with pH dependency and further confirmed on volunteers. In addition, APT imaging at 3.5 ppm using B(1,rms) at 1.0 μT performed on two human brains with different pathophysiological conditions indicated appropriate ATP effect. Japanese Society for Magnetic Resonance in Medicine 2017-05-31 /pmc/articles/PMC5760238/ /pubmed/28566586 http://dx.doi.org/10.2463/mrms.tn.2016-0069 Text en © 2017 Japanese Society for Magnetic Resonance in Medicine This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Technical Note
Kanazawa, Yuki
Fushimi, Yasutaka
Sakashita, Naotaka
Okada, Tomohisa
Arakawa, Yoshiki
Miyazaki, Mitsue
B(1) Power Optimization for Chemical Exchange Saturation Transfer Imaging: A Phantom Study Using Egg White for Amide Proton Transfer Imaging Applications in the Human Brain
title B(1) Power Optimization for Chemical Exchange Saturation Transfer Imaging: A Phantom Study Using Egg White for Amide Proton Transfer Imaging Applications in the Human Brain
title_full B(1) Power Optimization for Chemical Exchange Saturation Transfer Imaging: A Phantom Study Using Egg White for Amide Proton Transfer Imaging Applications in the Human Brain
title_fullStr B(1) Power Optimization for Chemical Exchange Saturation Transfer Imaging: A Phantom Study Using Egg White for Amide Proton Transfer Imaging Applications in the Human Brain
title_full_unstemmed B(1) Power Optimization for Chemical Exchange Saturation Transfer Imaging: A Phantom Study Using Egg White for Amide Proton Transfer Imaging Applications in the Human Brain
title_short B(1) Power Optimization for Chemical Exchange Saturation Transfer Imaging: A Phantom Study Using Egg White for Amide Proton Transfer Imaging Applications in the Human Brain
title_sort b(1) power optimization for chemical exchange saturation transfer imaging: a phantom study using egg white for amide proton transfer imaging applications in the human brain
topic Technical Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760238/
https://www.ncbi.nlm.nih.gov/pubmed/28566586
http://dx.doi.org/10.2463/mrms.tn.2016-0069
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