Longitudinal Assessment of Dentate Nuclei Relaxometry during Massive Gadobutrol Exposure

We report the assessment of Dentate Nuclei (DN) R1 (1/T(1)) and R2* ([Formula: see text]) values in a patient with relapsing-remitting Multiple Sclerosis, exposed to 22 standard (0.1 mmol/kg) doses of gadobutrol, who underwent eight relaxometric MR measurements within 2 years. DN R1 did not signific...

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Detalles Bibliográficos
Autores principales: Tedeschi, Enrico, Cocozza, Sirio, Borrelli, Pasquale, Ugga, Lorenzo, Morra, Vincenzo Brescia, Palma, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society for Magnetic Resonance in Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760240/
https://www.ncbi.nlm.nih.gov/pubmed/28367903
http://dx.doi.org/10.2463/mrms.cr.2016-0137
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author Tedeschi, Enrico
Cocozza, Sirio
Borrelli, Pasquale
Ugga, Lorenzo
Morra, Vincenzo Brescia
Palma, Giuseppe
author_facet Tedeschi, Enrico
Cocozza, Sirio
Borrelli, Pasquale
Ugga, Lorenzo
Morra, Vincenzo Brescia
Palma, Giuseppe
author_sort Tedeschi, Enrico
collection PubMed
description We report the assessment of Dentate Nuclei (DN) R1 (1/T(1)) and R2* ([Formula: see text]) values in a patient with relapsing-remitting Multiple Sclerosis, exposed to 22 standard (0.1 mmol/kg) doses of gadobutrol, who underwent eight relaxometric MR measurements within 2 years. DN R1 did not significantly increase nor correlated with cumulative gadobutrol administration, even after a total dose of 130 ml. Likewise, DN R2* relaxometry remained unchanged. In conclusion, massive gadobutrol exposure did not induce significant DN relaxometry changes.
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spelling pubmed-57602402018-01-19 Longitudinal Assessment of Dentate Nuclei Relaxometry during Massive Gadobutrol Exposure Tedeschi, Enrico Cocozza, Sirio Borrelli, Pasquale Ugga, Lorenzo Morra, Vincenzo Brescia Palma, Giuseppe Magn Reson Med Sci Case Report We report the assessment of Dentate Nuclei (DN) R1 (1/T(1)) and R2* ([Formula: see text]) values in a patient with relapsing-remitting Multiple Sclerosis, exposed to 22 standard (0.1 mmol/kg) doses of gadobutrol, who underwent eight relaxometric MR measurements within 2 years. DN R1 did not significantly increase nor correlated with cumulative gadobutrol administration, even after a total dose of 130 ml. Likewise, DN R2* relaxometry remained unchanged. In conclusion, massive gadobutrol exposure did not induce significant DN relaxometry changes. Japanese Society for Magnetic Resonance in Medicine 2017-03-27 /pmc/articles/PMC5760240/ /pubmed/28367903 http://dx.doi.org/10.2463/mrms.cr.2016-0137 Text en © 2017 Japanese Society for Magnetic Resonance in Medicine This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Case Report
Tedeschi, Enrico
Cocozza, Sirio
Borrelli, Pasquale
Ugga, Lorenzo
Morra, Vincenzo Brescia
Palma, Giuseppe
Longitudinal Assessment of Dentate Nuclei Relaxometry during Massive Gadobutrol Exposure
title Longitudinal Assessment of Dentate Nuclei Relaxometry during Massive Gadobutrol Exposure
title_full Longitudinal Assessment of Dentate Nuclei Relaxometry during Massive Gadobutrol Exposure
title_fullStr Longitudinal Assessment of Dentate Nuclei Relaxometry during Massive Gadobutrol Exposure
title_full_unstemmed Longitudinal Assessment of Dentate Nuclei Relaxometry during Massive Gadobutrol Exposure
title_short Longitudinal Assessment of Dentate Nuclei Relaxometry during Massive Gadobutrol Exposure
title_sort longitudinal assessment of dentate nuclei relaxometry during massive gadobutrol exposure
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760240/
https://www.ncbi.nlm.nih.gov/pubmed/28367903
http://dx.doi.org/10.2463/mrms.cr.2016-0137
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