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RNA-Independent DNA Cleavage Activities of Cas9 and Cas12a

CRISPR-Cas systems provide bacteria and archaea with sequence-specific protection against invading mobile genetic elements. In the presence of divalent metal ions, Cas9 and Cas12a (formerly Cpf1) proteins target and cleave DNA that is complementary to a cognate guide RNA. The recognition of a protos...

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Detalles Bibliográficos
Autores principales:	Sundaresan, Ramya, Parameshwaran, Hari Priya, Yogesha, S.D., Keilbarth, Mark Walter, Rajan, Rakhi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760271/ https://www.ncbi.nlm.nih.gov/pubmed/29281823 http://dx.doi.org/10.1016/j.celrep.2017.11.100

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