Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function

Thyroid hormone (TH) is critical for the maintenance of cellular homeostasis during stress responses, but its role in lung fibrosis is unknown. Here, we found that the activity and expression of iodothyronine deiodinase 2 (DIO2), an enzyme that activates TH, was higher in lungs of patients with idio...

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Detalles Bibliográficos
Autores principales: Yu, Guoying, Tzouvelekis, Argyris, Wang, Rong, Herazo-Maya, Jose D., Ibarra, Gabriel H., Srivastava, Anup, de Castro, Joao Pedro Werneck, DeIuliis, Giuseppe, Ahangari, Farida, Woolard, Tony, Aurelien, Nachelle, e Drigo, Rafael Arrojo, Gan, Ye, Graham, Morven, Liu, Xinran, Homer, Robert J., Scanlan, Thomas S., Mannam, Praveen, Lee, Patty J., Herzog, Erica L., Bianco, Antonio C., Kaminski, Naftali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760280/
https://www.ncbi.nlm.nih.gov/pubmed/29200204
http://dx.doi.org/10.1038/nm.4447

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