cGAS drives non-canonical inflammasome activation in age-related macular degeneration

Geographic atrophy is a blinding form of age-related macular degeneration characterized by death of the retinal pigmented epithelium (RPE). In this disease, the RPE displays evidence of DICER1 deficiency, resultant accumulation of endogenous Alu retroelement RNA, and NLRP3 inflammasome activation. H...

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Detalles Bibliográficos
Autores principales: Kerur, Nagaraj, Fukuda, Shinichi, Banerjee, Daipayan, Kim, Younghee, Fu, Dongxu, Apicella, Ivana, Varshney, Akhil, Yasuma, Reo, Fowler, Benjamin J., Baghdasaryan, Elmira, Marion, Kenneth M., Huang, Xiwen, Yasuma, Tetsuhiro, Hirano, Yoshio, Serbulea, Vlad, Ambati, Meenakshi, Ambati, Vidya L., Kajiwara, Yuji, Ambati, Kameshwari, Bastos-Carvalho, Ana, Ogura, Yuichiro, Terasaki, Hiroko, Oshika, Tetsuro, Kim, Kyung Bo, Hinton, David R., Leitinger, Norbert, Cambier, John C., Buxbaum, Joseph D., Kenney, M. Cristina, Jazwinski, S. Michal, Nagai, Hiroshi, Hara, Isao, West, A. Phillip, Fitzgerald, Katherine A., Sadda, SriniVas R., Gelfand, Bradley D., Ambati, Jayakrishna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760363/
https://www.ncbi.nlm.nih.gov/pubmed/29176737
http://dx.doi.org/10.1038/nm.4450

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