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Genetic determinants for chemo- and radiotherapy resistance in bladder cancer

Bladder cancer (BCa) is burdened by high rates of chemo- and radio-resistance. We reviewed and summarized the current evidence regarding the genetic determinants of resistance in patients treated with chemotherapy and/or radiotherapy (RT) for BCa. Genetic heterogeneity may preexist to treatment aris...

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Autores principales: Mari, Andrea, D’Andrea, David, Abufaraj, Mohammad, Foerster, Beat, Kimura, Shoji, Shariat, Shahrokh F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760393/
https://www.ncbi.nlm.nih.gov/pubmed/29354495
http://dx.doi.org/10.21037/tau.2017.08.19
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author Mari, Andrea
D’Andrea, David
Abufaraj, Mohammad
Foerster, Beat
Kimura, Shoji
Shariat, Shahrokh F.
author_facet Mari, Andrea
D’Andrea, David
Abufaraj, Mohammad
Foerster, Beat
Kimura, Shoji
Shariat, Shahrokh F.
author_sort Mari, Andrea
collection PubMed
description Bladder cancer (BCa) is burdened by high rates of chemo- and radio-resistance. We reviewed and summarized the current evidence regarding the genetic determinants of resistance in patients treated with chemotherapy and/or radiotherapy (RT) for BCa. Genetic heterogeneity may preexist to treatment arising with tumorigenesis or increasing progressively during the treatment. Several biological pathways seem to be involved in the cellular response to treatment. These pathways comprehend mechanisms leading to modify the intracellular concentration of the drug, mechanisms leading to increase the repair of DNA damage caused by the treatment, mechanisms leading to increase cell survival, despite DNA damage, acting on the signaling pathways affecting apoptosis, mechanisms promoting autophagy. In the present review, we focused on the genetic determinants of resistance affecting the aforementioned mechanisms.
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spelling pubmed-57603932018-01-19 Genetic determinants for chemo- and radiotherapy resistance in bladder cancer Mari, Andrea D’Andrea, David Abufaraj, Mohammad Foerster, Beat Kimura, Shoji Shariat, Shahrokh F. Transl Androl Urol Review Article Bladder cancer (BCa) is burdened by high rates of chemo- and radio-resistance. We reviewed and summarized the current evidence regarding the genetic determinants of resistance in patients treated with chemotherapy and/or radiotherapy (RT) for BCa. Genetic heterogeneity may preexist to treatment arising with tumorigenesis or increasing progressively during the treatment. Several biological pathways seem to be involved in the cellular response to treatment. These pathways comprehend mechanisms leading to modify the intracellular concentration of the drug, mechanisms leading to increase the repair of DNA damage caused by the treatment, mechanisms leading to increase cell survival, despite DNA damage, acting on the signaling pathways affecting apoptosis, mechanisms promoting autophagy. In the present review, we focused on the genetic determinants of resistance affecting the aforementioned mechanisms. AME Publishing Company 2017-12 /pmc/articles/PMC5760393/ /pubmed/29354495 http://dx.doi.org/10.21037/tau.2017.08.19 Text en 2017 Translational Andrology and Urology. All rights reserved.
spellingShingle Review Article
Mari, Andrea
D’Andrea, David
Abufaraj, Mohammad
Foerster, Beat
Kimura, Shoji
Shariat, Shahrokh F.
Genetic determinants for chemo- and radiotherapy resistance in bladder cancer
title Genetic determinants for chemo- and radiotherapy resistance in bladder cancer
title_full Genetic determinants for chemo- and radiotherapy resistance in bladder cancer
title_fullStr Genetic determinants for chemo- and radiotherapy resistance in bladder cancer
title_full_unstemmed Genetic determinants for chemo- and radiotherapy resistance in bladder cancer
title_short Genetic determinants for chemo- and radiotherapy resistance in bladder cancer
title_sort genetic determinants for chemo- and radiotherapy resistance in bladder cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760393/
https://www.ncbi.nlm.nih.gov/pubmed/29354495
http://dx.doi.org/10.21037/tau.2017.08.19
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