MicroRNA-155—at the Critical Interface of Innate and Adaptive Immunity in Arthritis

MicroRNAs (miRNAs) are small non-coding RNAs that fine-tune the cell response to a changing environment by modulating the cell transcriptome. miR-155 is a multifunctional miRNA enriched in cells of the immune system and is indispensable for the immune response. However, when deregulated, miR-155 con...

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Autores principales: Alivernini, Stefano, Gremese, Elisa, McSharry, Charles, Tolusso, Barbara, Ferraccioli, Gianfranco, McInnes, Iain B., Kurowska-Stolarska, Mariola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760508/
https://www.ncbi.nlm.nih.gov/pubmed/29354135
http://dx.doi.org/10.3389/fimmu.2017.01932
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author Alivernini, Stefano
Gremese, Elisa
McSharry, Charles
Tolusso, Barbara
Ferraccioli, Gianfranco
McInnes, Iain B.
Kurowska-Stolarska, Mariola
author_facet Alivernini, Stefano
Gremese, Elisa
McSharry, Charles
Tolusso, Barbara
Ferraccioli, Gianfranco
McInnes, Iain B.
Kurowska-Stolarska, Mariola
author_sort Alivernini, Stefano
collection PubMed
description MicroRNAs (miRNAs) are small non-coding RNAs that fine-tune the cell response to a changing environment by modulating the cell transcriptome. miR-155 is a multifunctional miRNA enriched in cells of the immune system and is indispensable for the immune response. However, when deregulated, miR-155 contributes to the development of chronic inflammation, autoimmunity, cancer, and fibrosis. Herein, we review the evidence for the pathogenic role of miR-155 in driving aberrant activation of the immune system in rheumatoid arthritis, and its potential as a disease biomarker and therapeutic target.
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spelling pubmed-57605082018-01-19 MicroRNA-155—at the Critical Interface of Innate and Adaptive Immunity in Arthritis Alivernini, Stefano Gremese, Elisa McSharry, Charles Tolusso, Barbara Ferraccioli, Gianfranco McInnes, Iain B. Kurowska-Stolarska, Mariola Front Immunol Immunology MicroRNAs (miRNAs) are small non-coding RNAs that fine-tune the cell response to a changing environment by modulating the cell transcriptome. miR-155 is a multifunctional miRNA enriched in cells of the immune system and is indispensable for the immune response. However, when deregulated, miR-155 contributes to the development of chronic inflammation, autoimmunity, cancer, and fibrosis. Herein, we review the evidence for the pathogenic role of miR-155 in driving aberrant activation of the immune system in rheumatoid arthritis, and its potential as a disease biomarker and therapeutic target. Frontiers Media S.A. 2018-01-05 /pmc/articles/PMC5760508/ /pubmed/29354135 http://dx.doi.org/10.3389/fimmu.2017.01932 Text en Copyright © 2018 Alivernini, Gremese, McSharry, Tolusso, Ferraccioli, McInnes and Kurowska-Stolarska. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Alivernini, Stefano
Gremese, Elisa
McSharry, Charles
Tolusso, Barbara
Ferraccioli, Gianfranco
McInnes, Iain B.
Kurowska-Stolarska, Mariola
MicroRNA-155—at the Critical Interface of Innate and Adaptive Immunity in Arthritis
title MicroRNA-155—at the Critical Interface of Innate and Adaptive Immunity in Arthritis
title_full MicroRNA-155—at the Critical Interface of Innate and Adaptive Immunity in Arthritis
title_fullStr MicroRNA-155—at the Critical Interface of Innate and Adaptive Immunity in Arthritis
title_full_unstemmed MicroRNA-155—at the Critical Interface of Innate and Adaptive Immunity in Arthritis
title_short MicroRNA-155—at the Critical Interface of Innate and Adaptive Immunity in Arthritis
title_sort microrna-155—at the critical interface of innate and adaptive immunity in arthritis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760508/
https://www.ncbi.nlm.nih.gov/pubmed/29354135
http://dx.doi.org/10.3389/fimmu.2017.01932
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