Modeling tumor immunity of mouse glioblastoma by exhausted CD8(+) T cells

T cell exhaustion occurs during chronic infection and cancers. Programmed cell death protein-1 (PD-1) is a major inhibitory checkpoint receptor involved in T cell exhaustion. Blocking antibodies (Abs) against PD-1 or its ligand, PD-L1, have been shown to reverse T cell exhaustion during chronic infe...

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Detalles Bibliográficos
Autores principales: Nakashima, Hiroshi, Alayo, Quazim A., Penaloza-MacMaster, Pablo, Freeman, Gordon J., Kuchroo, Vijay K., Reardon, David A., Fernandez, Soledad, Caligiuri, Michael, Chiocca, E. Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760520/
https://www.ncbi.nlm.nih.gov/pubmed/29317703
http://dx.doi.org/10.1038/s41598-017-18540-2

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