Natural Killer Cell-Based Immunotherapy in Gynecologic Malignancy: A Review

Harnessing the immune system has proven an effective therapy in treating malignancies. Since the discovery of natural killer (NK) cells, strategies aimed to manipulate and augment their effector function against cancer have been the subject of intense research. Recent progress in the immunobiology o...

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Autores principales: Uppendahl, Locke D., Dahl, Carly M., Miller, Jeffrey S., Felices, Martin, Geller, Melissa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760535/
https://www.ncbi.nlm.nih.gov/pubmed/29354116
http://dx.doi.org/10.3389/fimmu.2017.01825
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author Uppendahl, Locke D.
Dahl, Carly M.
Miller, Jeffrey S.
Felices, Martin
Geller, Melissa A.
author_facet Uppendahl, Locke D.
Dahl, Carly M.
Miller, Jeffrey S.
Felices, Martin
Geller, Melissa A.
author_sort Uppendahl, Locke D.
collection PubMed
description Harnessing the immune system has proven an effective therapy in treating malignancies. Since the discovery of natural killer (NK) cells, strategies aimed to manipulate and augment their effector function against cancer have been the subject of intense research. Recent progress in the immunobiology of NK cells has led to the development of promising therapeutic approaches. In this review, we will focus on the recent advances in NK cell immunobiology and the clinical application of NK cell immunotherapy in ovarian, cervical, and uterine cancer.
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spelling pubmed-57605352018-01-19 Natural Killer Cell-Based Immunotherapy in Gynecologic Malignancy: A Review Uppendahl, Locke D. Dahl, Carly M. Miller, Jeffrey S. Felices, Martin Geller, Melissa A. Front Immunol Immunology Harnessing the immune system has proven an effective therapy in treating malignancies. Since the discovery of natural killer (NK) cells, strategies aimed to manipulate and augment their effector function against cancer have been the subject of intense research. Recent progress in the immunobiology of NK cells has led to the development of promising therapeutic approaches. In this review, we will focus on the recent advances in NK cell immunobiology and the clinical application of NK cell immunotherapy in ovarian, cervical, and uterine cancer. Frontiers Media S.A. 2018-01-05 /pmc/articles/PMC5760535/ /pubmed/29354116 http://dx.doi.org/10.3389/fimmu.2017.01825 Text en Copyright © 2018 Uppendahl, Dahl, Miller, Felices and Geller. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Uppendahl, Locke D.
Dahl, Carly M.
Miller, Jeffrey S.
Felices, Martin
Geller, Melissa A.
Natural Killer Cell-Based Immunotherapy in Gynecologic Malignancy: A Review
title Natural Killer Cell-Based Immunotherapy in Gynecologic Malignancy: A Review
title_full Natural Killer Cell-Based Immunotherapy in Gynecologic Malignancy: A Review
title_fullStr Natural Killer Cell-Based Immunotherapy in Gynecologic Malignancy: A Review
title_full_unstemmed Natural Killer Cell-Based Immunotherapy in Gynecologic Malignancy: A Review
title_short Natural Killer Cell-Based Immunotherapy in Gynecologic Malignancy: A Review
title_sort natural killer cell-based immunotherapy in gynecologic malignancy: a review
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760535/
https://www.ncbi.nlm.nih.gov/pubmed/29354116
http://dx.doi.org/10.3389/fimmu.2017.01825
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