SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-κB pathway

Sirtuins are NAD(+)-dependent deacetylases that facilitate cellular stress response. They include SirT6, which protects genome stability and regulates metabolic homeostasis through gene silencing, and whose loss induces an accelerated aging phenotype directly linked to hyperactivation of the NF-κB p...

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Detalles Bibliográficos
Autores principales: Santos-Barriopedro, Irene, Bosch-Presegué, Laia, Marazuela-Duque, Anna, de la Torre, Carolina, Colomer, Carlota, Vazquez, Berta N., Fuhrmann, Thomas, Martínez-Pastor, Bárbara, Lu, Wenfu, Braun, Thomas, Bober, Eva, Jenuwein, Thomas, Serrano, Lourdes, Esteller, Manel, Chen, Zhenbang, Barceló-Batllori, Silvia, Mostoslavsky, Raúl, Espinosa, Lluis, Vaquero, Alejandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760577/
https://www.ncbi.nlm.nih.gov/pubmed/29317652
http://dx.doi.org/10.1038/s41467-017-02586-x

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