Cargando…

Correlates of Level and Loss of Grip Strength in Later Life: Findings from the English Longitudinal Study of Ageing and the Hertfordshire Cohort Study

Characterisation of grip strength (GS) using isometric dynamometry is central to the definition of sarcopenia. Determinants of low GS include: older age, shorter stature, low physical activity, poor nutrition, socioeconomic disadvantage and multimorbidity. Less is known about risk factors for accele...

Descripción completa

Detalles Bibliográficos
Autores principales: Syddall, H. E., Westbury, L. D., Shaw, S. C., Dennison, E. M., Cooper, C., Gale, C. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760591/
https://www.ncbi.nlm.nih.gov/pubmed/29058059
http://dx.doi.org/10.1007/s00223-017-0337-5
_version_ 1783291388611264512
author Syddall, H. E.
Westbury, L. D.
Shaw, S. C.
Dennison, E. M.
Cooper, C.
Gale, C. R.
author_facet Syddall, H. E.
Westbury, L. D.
Shaw, S. C.
Dennison, E. M.
Cooper, C.
Gale, C. R.
author_sort Syddall, H. E.
collection PubMed
description Characterisation of grip strength (GS) using isometric dynamometry is central to the definition of sarcopenia. Determinants of low GS include: older age, shorter stature, low physical activity, poor nutrition, socioeconomic disadvantage and multimorbidity. Less is known about risk factors for accelerated loss of GS. We investigated determinants of level and 8-year loss of GS in 3703 men and women (aged 52–82 years) in the English Longitudinal Study of Ageing (ELSA). Four hundred and forty-one men and women (aged 59–71 years) who participated in a 10-year follow-up of the Hertfordshire Cohort Study (HCS) were used for replication. Variables were harmonised between cohorts. Change in GS was characterised using mixed-effects models in ELSA and a residual change approach in HCS and analysed for men and women combined. Men in ELSA and HCS had higher average levels of GS at baseline, and accelerated rates of loss, compared with women. In ELSA, older age, shorter stature and multimorbidity were correlated with lower level, and accelerated rate of loss, of GS in both sexes (accelerated loss of 0.04 (95% CI 0.00–0.08) standard deviation scores per additional morbidity after multivariable adjustment). Socioeconomic disadvantage, low level of physical activity and poorer self-reported health were also correlated with low GS level, but not loss rate, after multivariable adjustment. Analysis in HCS yielded similar results. Our results identify multimorbidity as a modifiable determinant of loss of muscle strength in later life, and raise the possibility that developmental influences may impact on rate of involutional decline in muscle strength. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00223-017-0337-5) contains supplementary material, which is available to authorised users.
format Online
Article
Text
id pubmed-5760591
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-57605912018-01-22 Correlates of Level and Loss of Grip Strength in Later Life: Findings from the English Longitudinal Study of Ageing and the Hertfordshire Cohort Study Syddall, H. E. Westbury, L. D. Shaw, S. C. Dennison, E. M. Cooper, C. Gale, C. R. Calcif Tissue Int Original Research Characterisation of grip strength (GS) using isometric dynamometry is central to the definition of sarcopenia. Determinants of low GS include: older age, shorter stature, low physical activity, poor nutrition, socioeconomic disadvantage and multimorbidity. Less is known about risk factors for accelerated loss of GS. We investigated determinants of level and 8-year loss of GS in 3703 men and women (aged 52–82 years) in the English Longitudinal Study of Ageing (ELSA). Four hundred and forty-one men and women (aged 59–71 years) who participated in a 10-year follow-up of the Hertfordshire Cohort Study (HCS) were used for replication. Variables were harmonised between cohorts. Change in GS was characterised using mixed-effects models in ELSA and a residual change approach in HCS and analysed for men and women combined. Men in ELSA and HCS had higher average levels of GS at baseline, and accelerated rates of loss, compared with women. In ELSA, older age, shorter stature and multimorbidity were correlated with lower level, and accelerated rate of loss, of GS in both sexes (accelerated loss of 0.04 (95% CI 0.00–0.08) standard deviation scores per additional morbidity after multivariable adjustment). Socioeconomic disadvantage, low level of physical activity and poorer self-reported health were also correlated with low GS level, but not loss rate, after multivariable adjustment. Analysis in HCS yielded similar results. Our results identify multimorbidity as a modifiable determinant of loss of muscle strength in later life, and raise the possibility that developmental influences may impact on rate of involutional decline in muscle strength. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00223-017-0337-5) contains supplementary material, which is available to authorised users. Springer US 2017-10-22 2018 /pmc/articles/PMC5760591/ /pubmed/29058059 http://dx.doi.org/10.1007/s00223-017-0337-5 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Research
Syddall, H. E.
Westbury, L. D.
Shaw, S. C.
Dennison, E. M.
Cooper, C.
Gale, C. R.
Correlates of Level and Loss of Grip Strength in Later Life: Findings from the English Longitudinal Study of Ageing and the Hertfordshire Cohort Study
title Correlates of Level and Loss of Grip Strength in Later Life: Findings from the English Longitudinal Study of Ageing and the Hertfordshire Cohort Study
title_full Correlates of Level and Loss of Grip Strength in Later Life: Findings from the English Longitudinal Study of Ageing and the Hertfordshire Cohort Study
title_fullStr Correlates of Level and Loss of Grip Strength in Later Life: Findings from the English Longitudinal Study of Ageing and the Hertfordshire Cohort Study
title_full_unstemmed Correlates of Level and Loss of Grip Strength in Later Life: Findings from the English Longitudinal Study of Ageing and the Hertfordshire Cohort Study
title_short Correlates of Level and Loss of Grip Strength in Later Life: Findings from the English Longitudinal Study of Ageing and the Hertfordshire Cohort Study
title_sort correlates of level and loss of grip strength in later life: findings from the english longitudinal study of ageing and the hertfordshire cohort study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760591/
https://www.ncbi.nlm.nih.gov/pubmed/29058059
http://dx.doi.org/10.1007/s00223-017-0337-5
work_keys_str_mv AT syddallhe correlatesoflevelandlossofgripstrengthinlaterlifefindingsfromtheenglishlongitudinalstudyofageingandthehertfordshirecohortstudy
AT westburyld correlatesoflevelandlossofgripstrengthinlaterlifefindingsfromtheenglishlongitudinalstudyofageingandthehertfordshirecohortstudy
AT shawsc correlatesoflevelandlossofgripstrengthinlaterlifefindingsfromtheenglishlongitudinalstudyofageingandthehertfordshirecohortstudy
AT dennisonem correlatesoflevelandlossofgripstrengthinlaterlifefindingsfromtheenglishlongitudinalstudyofageingandthehertfordshirecohortstudy
AT cooperc correlatesoflevelandlossofgripstrengthinlaterlifefindingsfromtheenglishlongitudinalstudyofageingandthehertfordshirecohortstudy
AT galecr correlatesoflevelandlossofgripstrengthinlaterlifefindingsfromtheenglishlongitudinalstudyofageingandthehertfordshirecohortstudy