Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases

The recently discovered histone post-translational modification crotonylation connects cellular metabolism to gene regulation. Its regulation and tissue-specific functions are poorly understood. We characterize histone crotonylation in intestinal epithelia and find that histone H3 crotonylation at l...

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Detalles Bibliográficos
Autores principales: Fellows, Rachel, Denizot, Jérémy, Stellato, Claudia, Cuomo, Alessandro, Jain, Payal, Stoyanova, Elena, Balázsi, Szabina, Hajnády, Zoltán, Liebert, Anke, Kazakevych, Juri, Blackburn, Hector, Corrêa, Renan Oliveira, Fachi, José Luís, Sato, Fabio Takeo, Ribeiro, Willian R., Ferreira, Caroline Marcantonio, Perée, Hélène, Spagnuolo, Mariangela, Mattiuz, Raphaël, Matolcsi, Csaba, Guedes, Joana, Clark, Jonathan, Veldhoen, Marc, Bonaldi, Tiziana, Vinolo, Marco Aurélio Ramirez, Varga-Weisz, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760624/
https://www.ncbi.nlm.nih.gov/pubmed/29317660
http://dx.doi.org/10.1038/s41467-017-02651-5

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