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Experimental noise cutoff boosts inferability of transcriptional networks in large-scale gene-deletion studies

Generating a comprehensive map of molecular interactions in living cells is difficult and great efforts are undertaken to infer molecular interactions from large-scale perturbation experiments. Here, we develop the analytical and numerical tools to quantify the fundamental limits for inferring trans...

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Detalles Bibliográficos
Autores principales: Blum, C. F., Heramvand, N., Khonsari, A. S., Kollmann, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760630/
https://www.ncbi.nlm.nih.gov/pubmed/29317620
http://dx.doi.org/10.1038/s41467-017-02489-x