Determining direct binders of the Androgen Receptor using a high-throughput Cellular Thermal Shift Assay

Androgen Receptor (AR) is a key driver in prostate cancer. Direct targeting of AR has valuable therapeutic potential. However, the lack of disease relevant cellular methodologies capable of discriminating between inhibitors that directly bind AR and those that instead act on AR co-regulators has mad...

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Detalles Bibliográficos
Autores principales: Shaw, Joseph, Leveridge, Mathew, Norling, Charlotta, Karén, Jakob, Molina, Daniel Martinez, O’Neill, Daniel, Dowling, James E., Davey, Paul, Cowan, Suzanna, Dabrowski, Michael, Main, Martin, Gianni, Davide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760633/
https://www.ncbi.nlm.nih.gov/pubmed/29317749
http://dx.doi.org/10.1038/s41598-017-18650-x

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