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Spred2 Deficiency Exacerbates D-Galactosamine/Lipopolysaccharide -induced Acute Liver Injury in Mice via Increased Production of TNFα

Acute liver injury (ALI) is characterized by hepatocyte damage and inflammation. In the present study, we examined whether the absence of Sprouty-related EVH1-domain-containing protein 2 (Spred2), a negative regulator of the Ras/Raf/ERK/MAPK pathway, influences ALI induced by D-galactosamine (D-GalN...

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Detalles Bibliográficos
Autores principales:	Yang, Xu, Fujisawa, Masayoshi, Yoshimura, Teizo, Ohara, Toshiaki, Sato, Miwa, Mino, Megumi, San, Thar Htet, Gao, Tong, Kunkel, Steven L., Matsukawa, Akihiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760641/ https://www.ncbi.nlm.nih.gov/pubmed/29317674 http://dx.doi.org/10.1038/s41598-017-18380-0

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