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Pneumolysin induced mitochondrial dysfunction leads to release of mitochondrial DNA

Streptococcus pneumoniae (S.pn.) is the most common bacterial pathogen causing community acquired pneumonia. The pore-forming toxin pneumolysin (PLY) is the major virulence factor of S.pn. and supposed to affect alveolar epithelial cells thereby activating the immune system by liberation of danger-a...

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Detalles Bibliográficos
Autores principales:	Nerlich, Andreas, Mieth, Maren, Letsiou, Eleftheria, Fatykhova, Diana, Zscheppang, Katja, Imai-Matsushima, Aki, Meyer, Thomas F., Paasch, Lisa, Mitchell, Timothy J., Tönnies, Mario, Bauer, Torsten T., Schneider, Paul, Neudecker, Jens, Rückert, Jens C., Eggeling, Stephan, Schimek, Maria, Witzenrath, Martin, Suttorp, Norbert, Hippenstiel, Stefan, Hocke, Andreas C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760655/ https://www.ncbi.nlm.nih.gov/pubmed/29317705 http://dx.doi.org/10.1038/s41598-017-18468-7

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