Cargando…

Methylation in Mycobacterium tuberculosis is lineage specific with associated mutations present globally

DNA methylation is an epigenetic modification of the genome involved in regulating crucial cellular processes, including transcription and chromosome stability. Advances in PacBio sequencing technologies can be used to robustly reveal methylation sites. The methylome of the Mycobacterium tuberculosi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Phelan, Jody, de Sessions, Paola Florez, Tientcheu, Leopold, Perdigao, Joao, Machado, Diana, Hasan, Rumina, Hasan, Zahra, Bergval, Indra L., Anthony, Richard, McNerney, Ruth, Antonio, Martin, Portugal, Isabel, Viveiros, Miguel, Campino, Susana, Hibberd, Martin L., Clark, Taane G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760664/ https://www.ncbi.nlm.nih.gov/pubmed/29317751 http://dx.doi.org/10.1038/s41598-017-18188-y

Ejemplares similares

Emergence of multidrug-resistant Mycobacterium tuberculosis of the Beijing lineage in Portugal and Guinea-Bissau: a snapshot of moving clones by whole-genome sequencing
por: Perdigão, João, et al.
Publicado: (2020)

Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages
por: Phelan, Jody E., et al.
Publicado: (2016)

Functional genetic variation in pe/ppe genes contributes to diversity in Mycobacterium tuberculosis lineages and potential interactions with the human host
por: Gómez-González, Paula Josefina, et al.
Publicado: (2023)

Genome-wide analysis of Mycobacterium tuberculosis polymorphisms reveals lineage-specific associations with drug resistance
por: Oppong, Yaa E. A., et al.
Publicado: (2019)

Robust barcoding and identification of Mycobacterium tuberculosis lineages for epidemiological and clinical studies
por: Napier, Gary, et al.
Publicado: (2020)

Genetic diversity of candidate loci linked to Mycobacterium tuberculosis resistance to bedaquiline, delamanid and pretomanid
por: Gómez-González, Paula J., et al.
Publicado: (2021)

Machine Learning Predicts Accurately Mycobacterium tuberculosis Drug Resistance From Whole Genome Sequencing Data
por: Deelder, Wouter, et al.
Publicado: (2019)

Methylation analysis of Klebsiella pneumoniae from Portuguese hospitals
por: Spadar, Anton, et al.
Publicado: (2021)

A robust SNP barcode for typing Mycobacterium tuberculosis complex strains
por: Coll, Francesc, et al.
Publicado: (2014)

An integrated whole genome analysis of Mycobacterium tuberculosis reveals insights into relationship between its genome, transcriptome and methylome
por: Gomez-Gonzalez, Paula J., et al.
Publicado: (2019)

Integrating informatics tools and portable sequencing technology for rapid detection of resistance to anti-tuberculous drugs
por: Phelan, Jody E., et al.
Publicado: (2019)

Mixed infections in genotypic drug-resistant Mycobacterium tuberculosis
por: Wang, Linfeng, et al.
Publicado: (2023)

Primary macrophages and J774 cells respond differently to infection with Mycobacterium tuberculosis
por: Andreu, Nuria, et al.
Publicado: (2017)

Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance
por: Phelan, Jody, et al.
Publicado: (2016)

Whole Genome Sequencing Based Characterization of Extensively Drug-Resistant Mycobacterium tuberculosis Isolates from Pakistan
por: Ali, Asho, et al.
Publicado: (2015)

COVID-profiler: a webserver for the analysis of SARS-CoV-2 sequencing data
por: Phelan, Jody, et al.
Publicado: (2022)

Comparison of in silico predicted Mycobacterium tuberculosis spoligotypes and lineages from whole genome sequencing data
por: Napier, Gary, et al.
Publicado: (2023)

An integrated in silico immuno-genetic analytical platform provides insights into COVID-19 serological and vaccine targets
por: Ward, Daniel, et al.
Publicado: (2021)

Portable sequencing of Mycobacterium tuberculosis for clinical and epidemiological applications
por: Gómez-González, Paula J, et al.
Publicado: (2022)

Large-scale genomic analysis of Mycobacterium tuberculosis reveals extent of target and compensatory mutations linked to multi-drug resistant tuberculosis
por: Napier, Gary, et al.
Publicado: (2023)

The variability and reproducibility of whole genome sequencing technology for detecting resistance to anti-tuberculous drugs
por: Phelan, Jody, et al.
Publicado: (2016)

PolyTB: A genomic variation map for Mycobacterium tuberculosis
por: Coll, Francesc, et al.
Publicado: (2014)

Rapid determination of anti-tuberculosis drug resistance from whole-genome sequences
por: Coll, Francesc, et al.
Publicado: (2015)

Using genomics to understand the origin and dispersion of multidrug and extensively drug resistant tuberculosis in Portugal
por: Perdigão, João, et al.
Publicado: (2020)

Robust detection of point mutations involved in multidrug-resistant Mycobacterium tuberculosis in the presence of co-occurrent resistance markers
por: Libiseller-Egger, Julian, et al.
Publicado: (2020)

Characterisation of drug-resistant Mycobacterium tuberculosis mutations and transmission in Pakistan
por: Napier, Gary, et al.
Publicado: (2022)

A modified decision tree approach to improve the prediction and mutation discovery for drug resistance in Mycobacterium tuberculosis
por: Deelder, Wouter, et al.
Publicado: (2022)

Unraveling Mycobacterium tuberculosis genomic diversity and evolution in Lisbon, Portugal, a highly drug resistant setting
por: Perdigão, João, et al.
Publicado: (2014)

TB-ML—a framework for comparing machine learning approaches to predict drug resistance of Mycobacterium tuberculosis
por: Libiseller-Egger, Julian, et al.
Publicado: (2023)

Whole-genome sequencing resolves a polyclonal outbreak by extended-spectrum beta-lactam and carbapenem-resistant Klebsiella pneumoniae in a Portuguese tertiary-care hospital
por: Perdigão, João, et al.
Publicado: (2020)

Identifying mixed Mycobacterium tuberculosis infections from whole genome sequence data
por: Sobkowiak, Benjamin, et al.
Publicado: (2018)

Whole genome sequencing reveals large deletions and other loss of function mutations in Mycobacterium tuberculosis drug resistance genes
por: Gomes, Laura C., et al.
Publicado: (2021)

Zika might not be acting alone: Using an ecological study approach to investigate potential co-acting risk factors for an unusual pattern of microcephaly in Brazil
por: Campos, Monica C., et al.
Publicado: (2018)

Structural and Genomic Insights Into Pyrazinamide Resistance in Mycobacterium tuberculosis Underlie Differences Between Ancient and Modern Lineages
por: Tunstall, Tanushree, et al.
Publicado: (2021)

Whole genome sequencing of drug resistant Mycobacterium tuberculosis isolates from a high burden tuberculosis region of North West Pakistan
por: Jabbar, Abdul, et al.
Publicado: (2019)

Large-scale reference-free analysis of flavivirus sequences in Aedes aegypti whole genome DNA sequencing data
por: Spadar, Anton, et al.
Publicado: (2023)

Mycobacterium tuberculosis whole genome sequencing provides insights into the Manila strain and drug-resistance mutations in the Philippines
por: Phelan, Jody E., et al.
Publicado: (2019)

Feature weighted models to address lineage dependency in drug-resistance prediction from Mycobacterium tuberculosis genome sequences
por: Billows, Nina, et al.
Publicado: (2023)

Beijing Lineage of MDR Mycobacterium tuberculosis in Bulgaria, 2007–2011
por: Panaiotov, Stefan, et al.
Publicado: (2014)

SpolPred: rapid and accurate prediction of Mycobacterium tuberculosis spoligotypes from short genomic sequences
por: Coll, Francesc, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_8tbi13qs9sdf5u4iprdnf9ovja