Multiple entry pathways within the efflux transporter AcrB contribute to multidrug recognition

AcrB is the major multidrug exporter in Escherichia coli. Although several substrate-entrances have been identified, the specificity of these various transport paths remains unclear. Here we present evidence for a substrate channel (channel 3)  from the central cavity of the AcrB trimer, which is co...

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Detalles Bibliográficos
Autores principales: Zwama, Martijn, Yamasaki, Seiji, Nakashima, Ryosuke, Sakurai, Keisuke, Nishino, Kunihiko, Yamaguchi, Akihito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760665/
https://www.ncbi.nlm.nih.gov/pubmed/29317622
http://dx.doi.org/10.1038/s41467-017-02493-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760665/
https://www.ncbi.nlm.nih.gov/pubmed/29317622
http://dx.doi.org/10.1038/s41467-017-02493-1

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