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Single, very low rituximab doses in healthy volunteers - a pilot and a randomized trial: implications for dosing and biosimilarity testing

There are no dose-finding trials available for rituximab that could guide dosing in non-malignant diseases. We hypothesized that currently used doses (≥375 mg/m(2)) exceed several hundred-fold the half-maximal effective dose, which is most sensitive for detecting putative differences between biosim...

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Detalles Bibliográficos
Autores principales:	Schoergenhofer, Christian, Schwameis, Michael, Firbas, Christa, Bartko, Johann, Derhaschnig, Ulla, Mader, Robert M, Plaßmann, Raute Sunder, Jilma-Stohlawetz, Petra, Desai, Kalpna, Misra, Priya, Jäger, Ulrich, Jilma, Bernd
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760686/ https://www.ncbi.nlm.nih.gov/pubmed/29317666 http://dx.doi.org/10.1038/s41598-017-17934-6

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