Engineering human pluripotent stem cells into a functional skeletal muscle tissue

The generation of functional skeletal muscle tissues from human pluripotent stem cells (hPSCs) has not been reported. Here, we derive induced myogenic progenitor cells (iMPCs) via transient overexpression of Pax7 in paraxial mesoderm cells differentiated from hPSCs. In 2D culture, iMPCs readily diff...

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Detalles Bibliográficos
Autores principales: Rao, Lingjun, Qian, Ying, Khodabukus, Alastair, Ribar, Thomas, Bursac, Nenad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760720/
https://www.ncbi.nlm.nih.gov/pubmed/29317646
http://dx.doi.org/10.1038/s41467-017-02636-4

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