Phf8 histone demethylase deficiency causes cognitive impairments through the mTOR pathway

Epigenomic abnormalities caused by genetic mutation in epigenetic regulators can result in neurodevelopmental disorders, deficiency in neural plasticity and mental retardation. As a histone demethylase, plant homeodomain finger protein 8 (Phf8) is a candidate gene for syndromal and non-specific form...

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Detalles Bibliográficos
Autores principales: Chen, Xuemei, Wang, Shuai, Zhou, Ying, Han, Yanfei, Li, Shengtian, Xu, Qing, Xu, Longyong, Zhu, Ziqi, Deng, Youming, Yu, Lu, Song, Lulu, Chen, Adele Pin, Song, Juan, Takahashi, Eiki, He, Guang, He, Lin, Li, Weidong, Chen, Charlie Degui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760733/
https://www.ncbi.nlm.nih.gov/pubmed/29317619
http://dx.doi.org/10.1038/s41467-017-02531-y

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