Monitoring the hydrolyzation of aspirin during the dissolution testing for aspirin delayed-release tablets with a fiber-optic dissolution system

The purpose of this study was to investigate the hydrolyzation of aspirin during the process of dissolution testing for aspirin delayed-release tablets. Hydrolysis product of salicylic acid can result in adverse effects and affect the determination of dissolution rate assaying. In this study, the te...

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Detalles Bibliográficos
Autores principales: Wang, Yan, Xu, Ping-Ping, Li, Xin-Xia, Nie, Kun, Tuo, Ming-Fu, Kong, Bin, Chen, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760771/
https://www.ncbi.nlm.nih.gov/pubmed/29403772
http://dx.doi.org/10.1016/j.jpha.2012.06.002
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author Wang, Yan
Xu, Ping-Ping
Li, Xin-Xia
Nie, Kun
Tuo, Ming-Fu
Kong, Bin
Chen, Jian
author_facet Wang, Yan
Xu, Ping-Ping
Li, Xin-Xia
Nie, Kun
Tuo, Ming-Fu
Kong, Bin
Chen, Jian
author_sort Wang, Yan
collection PubMed
description The purpose of this study was to investigate the hydrolyzation of aspirin during the process of dissolution testing for aspirin delayed-release tablets. Hydrolysis product of salicylic acid can result in adverse effects and affect the determination of dissolution rate assaying. In this study, the technique of differential spectra was employed, which made it possible to monitor the dissolution testing in situ. The results showed that the hydrolyzation of aspirin made the percentage of salicylic acid exceed the limit of free salicylic acid (4.0), and the hydrolyzation may affect the quality detection of aspirin delayed-release tablets.
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spelling pubmed-57607712018-02-05 Monitoring the hydrolyzation of aspirin during the dissolution testing for aspirin delayed-release tablets with a fiber-optic dissolution system Wang, Yan Xu, Ping-Ping Li, Xin-Xia Nie, Kun Tuo, Ming-Fu Kong, Bin Chen, Jian J Pharm Anal Article The purpose of this study was to investigate the hydrolyzation of aspirin during the process of dissolution testing for aspirin delayed-release tablets. Hydrolysis product of salicylic acid can result in adverse effects and affect the determination of dissolution rate assaying. In this study, the technique of differential spectra was employed, which made it possible to monitor the dissolution testing in situ. The results showed that the hydrolyzation of aspirin made the percentage of salicylic acid exceed the limit of free salicylic acid (4.0), and the hydrolyzation may affect the quality detection of aspirin delayed-release tablets. Xi'an Jiaotong University 2012-10 2012-06-27 /pmc/articles/PMC5760771/ /pubmed/29403772 http://dx.doi.org/10.1016/j.jpha.2012.06.002 Text en © 2012 Xi'an Jiaotong University http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Article
Wang, Yan
Xu, Ping-Ping
Li, Xin-Xia
Nie, Kun
Tuo, Ming-Fu
Kong, Bin
Chen, Jian
Monitoring the hydrolyzation of aspirin during the dissolution testing for aspirin delayed-release tablets with a fiber-optic dissolution system
title Monitoring the hydrolyzation of aspirin during the dissolution testing for aspirin delayed-release tablets with a fiber-optic dissolution system
title_full Monitoring the hydrolyzation of aspirin during the dissolution testing for aspirin delayed-release tablets with a fiber-optic dissolution system
title_fullStr Monitoring the hydrolyzation of aspirin during the dissolution testing for aspirin delayed-release tablets with a fiber-optic dissolution system
title_full_unstemmed Monitoring the hydrolyzation of aspirin during the dissolution testing for aspirin delayed-release tablets with a fiber-optic dissolution system
title_short Monitoring the hydrolyzation of aspirin during the dissolution testing for aspirin delayed-release tablets with a fiber-optic dissolution system
title_sort monitoring the hydrolyzation of aspirin during the dissolution testing for aspirin delayed-release tablets with a fiber-optic dissolution system
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760771/
https://www.ncbi.nlm.nih.gov/pubmed/29403772
http://dx.doi.org/10.1016/j.jpha.2012.06.002
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