Flow injection chemiluminescence determination of loxoprofen and naproxen with the acidic permanganate-sulfite system

A novel flow injection chemiluminescence (CL) method for the determination of loxoprofen and naproxen was proposed based on the CL system of KMnO(4), and Na(2)SO(3) in acid media. The CL intensity of KMnO(4)-Na(2)SO(3) was greatly enhaneed in the presence of loxoprofen and naproxen. The mechanism of the CL reaction was studied by the kinetic proecss and UV-vis absorption and the conditions were optimized. Under optimized conditions, the CL intensity was linear with loxoprofen and naproxen concentration in the range of 7.0 × 10(−8) – 1.0 × 10(−5) g/mL and 2.0 × 10(−7) – 4.0 × 10(−6) g/mL with the detection limit of 2.0 × 10(−8) g/mL and 3.0 × 10(−8) g/mL (S/N = 3), respectively. Thc relative standard deviations were 2.39% and 1.37% for 5.0 × 10(−7) g/mL naproxen and 5.0 × 10(−7) g/mL loxoprofen (n = 10), respectively. The proposed method was satisfactorily applied to thc determination of loxoprofen and naproxen in pharmaceutical preparations.