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Pharmacokinetic behavior of 16-dehydropregnenolone after intramuscular administration in rats

The pharmacokinetics of 16-dehydropregnenolone (16-DHP), a sterols compound isolated from Solanum lyratum Thunb., was investigated in rats following a Single intramuscular administration (40 mg/kg). The concentration of 16-DHP in rat plasma was determined by a high Performance liquid chromatography...

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Autores principales: Yang, Hong-Ying, Zhang, Wen-Meng, Yang, Wen-Wen, Zhao, Ting, Sun, Li-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760801/
https://www.ncbi.nlm.nih.gov/pubmed/29403692
http://dx.doi.org/10.1016/S2095-1779(11)70023-5
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author Yang, Hong-Ying
Zhang, Wen-Meng
Yang, Wen-Wen
Zhao, Ting
Sun, Li-Xin
author_facet Yang, Hong-Ying
Zhang, Wen-Meng
Yang, Wen-Wen
Zhao, Ting
Sun, Li-Xin
author_sort Yang, Hong-Ying
collection PubMed
description The pharmacokinetics of 16-dehydropregnenolone (16-DHP), a sterols compound isolated from Solanum lyratum Thunb., was investigated in rats following a Single intramuscular administration (40 mg/kg). The concentration of 16-DHP in rat plasma was determined by a high Performance liquid chromatography (HPLC) method with UV detection. Levonorgestrel was used as the internal Standard (IS). The pharmacokinetic parameters of 16-DHP were derived by non-compartmental method. After a Single intramuscular administration, the maximum plasma concentration (C(max)) was (289 ± 25) ng/mL, time to reach C(max)(t(max)) was (0.38 ± 0.14) h, the elimination half-life (t(1/2)) was (2.5 ± 1.1) h, the area under the plasma concentration-time curve from time zero to the time of the last measurable concentration (AUC((0-t))) was (544 ± 73)ng · h/mL. The results indicated that 16-DHP was absorbed quickly and eliminated rapidly in rats after the intramuscular injection.
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spelling pubmed-57608012018-02-05 Pharmacokinetic behavior of 16-dehydropregnenolone after intramuscular administration in rats Yang, Hong-Ying Zhang, Wen-Meng Yang, Wen-Wen Zhao, Ting Sun, Li-Xin J Pharm Anal Original article The pharmacokinetics of 16-dehydropregnenolone (16-DHP), a sterols compound isolated from Solanum lyratum Thunb., was investigated in rats following a Single intramuscular administration (40 mg/kg). The concentration of 16-DHP in rat plasma was determined by a high Performance liquid chromatography (HPLC) method with UV detection. Levonorgestrel was used as the internal Standard (IS). The pharmacokinetic parameters of 16-DHP were derived by non-compartmental method. After a Single intramuscular administration, the maximum plasma concentration (C(max)) was (289 ± 25) ng/mL, time to reach C(max)(t(max)) was (0.38 ± 0.14) h, the elimination half-life (t(1/2)) was (2.5 ± 1.1) h, the area under the plasma concentration-time curve from time zero to the time of the last measurable concentration (AUC((0-t))) was (544 ± 73)ng · h/mL. The results indicated that 16-DHP was absorbed quickly and eliminated rapidly in rats after the intramuscular injection. Xi'an Jiaotong University 2011-05 2012-01-30 /pmc/articles/PMC5760801/ /pubmed/29403692 http://dx.doi.org/10.1016/S2095-1779(11)70023-5 Text en . http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Original article
Yang, Hong-Ying
Zhang, Wen-Meng
Yang, Wen-Wen
Zhao, Ting
Sun, Li-Xin
Pharmacokinetic behavior of 16-dehydropregnenolone after intramuscular administration in rats
title Pharmacokinetic behavior of 16-dehydropregnenolone after intramuscular administration in rats
title_full Pharmacokinetic behavior of 16-dehydropregnenolone after intramuscular administration in rats
title_fullStr Pharmacokinetic behavior of 16-dehydropregnenolone after intramuscular administration in rats
title_full_unstemmed Pharmacokinetic behavior of 16-dehydropregnenolone after intramuscular administration in rats
title_short Pharmacokinetic behavior of 16-dehydropregnenolone after intramuscular administration in rats
title_sort pharmacokinetic behavior of 16-dehydropregnenolone after intramuscular administration in rats
topic Original article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760801/
https://www.ncbi.nlm.nih.gov/pubmed/29403692
http://dx.doi.org/10.1016/S2095-1779(11)70023-5
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