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A complex genomic locus drives mtDNA replicase POLG expression to its disease‐related nervous system regions

DNA polymerase gamma (POLG), the mtDNA replicase, is a common cause of mitochondrial neurodegeneration. Why POLG defects especially cause central nervous system (CNS) diseases is unknown. We discovered a complex genomic regulatory locus for POLG, containing three functional CNS‐specific enhancers th...

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Detalles Bibliográficos
Autores principales:	Nikkanen, Joni, Landoni, Juan Cruz, Balboa, Diego, Haugas, Maarja, Partanen, Juha, Paetau, Anders, Isohanni, Pirjo, Brilhante, Virginia, Suomalainen, Anu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760859/ https://www.ncbi.nlm.nih.gov/pubmed/29109127 http://dx.doi.org/10.15252/emmm.201707993

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