Voltammetric behavior of sedative drug midazolam at glassy carbon electrode in solubilized systems

Redox behavior of midazolam was studied at a glassy carbon electrode in various buffer systems, supporting electrolytes and pH using differential pulse, square-wave and cyclic voltammetry. Based on its reduction behavior, a direct differential pulse voltammetric method has been developed and validat...

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Detalles Bibliográficos
Autores principales: Jain, Rajeev, Yadav, Rajeev Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760897/
https://www.ncbi.nlm.nih.gov/pubmed/29403731
http://dx.doi.org/10.1016/j.jpha.2011.11.008
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author Jain, Rajeev
Yadav, Rajeev Kumar
author_facet Jain, Rajeev
Yadav, Rajeev Kumar
author_sort Jain, Rajeev
collection PubMed
description Redox behavior of midazolam was studied at a glassy carbon electrode in various buffer systems, supporting electrolytes and pH using differential pulse, square-wave and cyclic voltammetry. Based on its reduction behavior, a direct differential pulse voltammetric method has been developed and validated for the determination of midazolam in parenteral dosage. Three well-defined peaks were observed in 0.1% SLS, Britton–Robinson (BR) buffer of pH 2.5. The effect of surfactants like sodium lauryl sulfate (SLS), cetyl trimethyl ammonium bromide (CTAB) and Tween 20 was studied. Among these surfactants SLS showed significant enhancement in reduction peak. The cathodic peak currents were directly proportional to the concentration of midazolam with correlation coefficient of 0.99.
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spelling pubmed-57608972018-02-05 Voltammetric behavior of sedative drug midazolam at glassy carbon electrode in solubilized systems Jain, Rajeev Yadav, Rajeev Kumar J Pharm Anal Article Redox behavior of midazolam was studied at a glassy carbon electrode in various buffer systems, supporting electrolytes and pH using differential pulse, square-wave and cyclic voltammetry. Based on its reduction behavior, a direct differential pulse voltammetric method has been developed and validated for the determination of midazolam in parenteral dosage. Three well-defined peaks were observed in 0.1% SLS, Britton–Robinson (BR) buffer of pH 2.5. The effect of surfactants like sodium lauryl sulfate (SLS), cetyl trimethyl ammonium bromide (CTAB) and Tween 20 was studied. Among these surfactants SLS showed significant enhancement in reduction peak. The cathodic peak currents were directly proportional to the concentration of midazolam with correlation coefficient of 0.99. Xi'an Jiaotong University 2012-04 2011-12-07 /pmc/articles/PMC5760897/ /pubmed/29403731 http://dx.doi.org/10.1016/j.jpha.2011.11.008 Text en © 2012 Xi'an Jiaotong University http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Article
Jain, Rajeev
Yadav, Rajeev Kumar
Voltammetric behavior of sedative drug midazolam at glassy carbon electrode in solubilized systems
title Voltammetric behavior of sedative drug midazolam at glassy carbon electrode in solubilized systems
title_full Voltammetric behavior of sedative drug midazolam at glassy carbon electrode in solubilized systems
title_fullStr Voltammetric behavior of sedative drug midazolam at glassy carbon electrode in solubilized systems
title_full_unstemmed Voltammetric behavior of sedative drug midazolam at glassy carbon electrode in solubilized systems
title_short Voltammetric behavior of sedative drug midazolam at glassy carbon electrode in solubilized systems
title_sort voltammetric behavior of sedative drug midazolam at glassy carbon electrode in solubilized systems
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760897/
https://www.ncbi.nlm.nih.gov/pubmed/29403731
http://dx.doi.org/10.1016/j.jpha.2011.11.008
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