Electrochemical study and application on rutin at chitosan/graphene films modified glassy carbon electrode

Graphene (G) was dispersed into 0.5% chitosan (Chit) solution, then the composite films were coated on glassy carbon electrode (GCE), the electrochemical behavior of rutin on a Chit/G modified GCE was investigated and the electrochemical parameters of rutin were calculated. Rutin effectively accumulated on the Chit/G/GCE and caused a pair of redox peaks at around 408 mV and 482 mV (vs. SCE) in 0.1 M phosphate buffer solution (pH 4.0). Under optimized conditions, the anodic peak current was linear to the rutin concentration in the range of 5×10(−7)–1.04×10(−5) M. The regression equation was: y=9.9219x–0.0025, r= 0.9958. The proposed method was successfully used for the determination of rutin content in tablet samples with satisfactory results.