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Fused-core particle technology in high-performance liquid chromatography: An overview
The advent of superficially porous particles (SPPs) for packed HPLC columns has changed the way that many practitioners have approached the problem of developing needed separations. The very high efficiency of such columns, combined with convenient operating conditions, modest back pressures and the...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Xi'an Jiaotong University
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760966/ https://www.ncbi.nlm.nih.gov/pubmed/29403832 http://dx.doi.org/10.1016/j.jpha.2013.02.005 |
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author | Kirkland, Joseph J. Schuster, Stephanie A. Johnson, William L. Boyes, Barry E. |
author_facet | Kirkland, Joseph J. Schuster, Stephanie A. Johnson, William L. Boyes, Barry E. |
author_sort | Kirkland, Joseph J. |
collection | PubMed |
description | The advent of superficially porous particles (SPPs) for packed HPLC columns has changed the way that many practitioners have approached the problem of developing needed separations. The very high efficiency of such columns, combined with convenient operating conditions, modest back pressures and the ability to use conventional HPLC instruments has resulted in intense basic studies of SPP technology, and widespread applications in many sciences. This report contains an overview of the SPP technology first developed in 2006 by Advanced Materials Technology, Inc., for sub-3-μm particles, then expanded into a family of SPP products with different particle sizes, pore sizes and other physical parameters. This approach was designed so that each particle of the family could be optimized for separating a particular group of compounds, usually based on solute size. |
format | Online Article Text |
id | pubmed-5760966 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Xi'an Jiaotong University |
record_format | MEDLINE/PubMed |
spelling | pubmed-57609662018-02-05 Fused-core particle technology in high-performance liquid chromatography: An overview Kirkland, Joseph J. Schuster, Stephanie A. Johnson, William L. Boyes, Barry E. J Pharm Anal Special Issue: HPLC in pharmaceutical analysis The advent of superficially porous particles (SPPs) for packed HPLC columns has changed the way that many practitioners have approached the problem of developing needed separations. The very high efficiency of such columns, combined with convenient operating conditions, modest back pressures and the ability to use conventional HPLC instruments has resulted in intense basic studies of SPP technology, and widespread applications in many sciences. This report contains an overview of the SPP technology first developed in 2006 by Advanced Materials Technology, Inc., for sub-3-μm particles, then expanded into a family of SPP products with different particle sizes, pore sizes and other physical parameters. This approach was designed so that each particle of the family could be optimized for separating a particular group of compounds, usually based on solute size. Xi'an Jiaotong University 2013-10 2013-02-27 /pmc/articles/PMC5760966/ /pubmed/29403832 http://dx.doi.org/10.1016/j.jpha.2013.02.005 Text en © 2013 Xi’an Jiaotong University. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/). |
spellingShingle | Special Issue: HPLC in pharmaceutical analysis Kirkland, Joseph J. Schuster, Stephanie A. Johnson, William L. Boyes, Barry E. Fused-core particle technology in high-performance liquid chromatography: An overview |
title | Fused-core particle technology in high-performance liquid chromatography: An overview |
title_full | Fused-core particle technology in high-performance liquid chromatography: An overview |
title_fullStr | Fused-core particle technology in high-performance liquid chromatography: An overview |
title_full_unstemmed | Fused-core particle technology in high-performance liquid chromatography: An overview |
title_short | Fused-core particle technology in high-performance liquid chromatography: An overview |
title_sort | fused-core particle technology in high-performance liquid chromatography: an overview |
topic | Special Issue: HPLC in pharmaceutical analysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760966/ https://www.ncbi.nlm.nih.gov/pubmed/29403832 http://dx.doi.org/10.1016/j.jpha.2013.02.005 |
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