Method development and validation of Guanfacine in rat plasma by liquid chromatography–tandem mass spectrometry: Application to a pharmacokinetic study

A selective, sensitive and high-throughput liquid chromatography–tandem mass spectrometry (LC–ESI-MS/MS) method has been developed and validated for the quantitation of Guanfacine in rat plasma. Sample clean-up involved liquid–liquid extraction (LLE) and 100 μL of rat plasma was used. YMC BASIC colu...

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Detalles Bibliográficos
Autores principales: Goparaju, Suryanarayana Murthy, Nandula, Yadagiri Srinivasa Murthy, Bannoth Kothapalli, Chandrasekher, Challa, B.R., Awen, Bahlul Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760995/
https://www.ncbi.nlm.nih.gov/pubmed/29403858
http://dx.doi.org/10.1016/j.jpha.2013.04.006

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