Application of LC–MS/MS for quantitative analysis of glucocorticoids and stimulants in biological fluids

Liquid chromatography tandem mass chromatography (LC–MS/MS) is an important hyphenated technique for quantitative analysis of drugs in biological fluids. Because of high sensitivity and selectivity, LC–MS/MS has been used for pharmacokinetic studies, metabolites identification in the plasma and urin...

Descripción completa

Detalles Bibliográficos
Autores principales: Haneef, Jamshed, Shaharyar, Mohammad, Husain, Asif, Rashid, Mohd, Mishra, Ravinesh, Parveen, Shama, Ahmed, Niyaz, Pal, Manoj, Kumar, Deepak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2013
Materias:
Review Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760999/
https://www.ncbi.nlm.nih.gov/pubmed/29403837
http://dx.doi.org/10.1016/j.jpha.2013.03.005
_version_ 1783291481559138304
author Haneef, Jamshed
Shaharyar, Mohammad
Husain, Asif
Rashid, Mohd
Mishra, Ravinesh
Parveen, Shama
Ahmed, Niyaz
Pal, Manoj
Kumar, Deepak
author_facet Haneef, Jamshed
Shaharyar, Mohammad
Husain, Asif
Rashid, Mohd
Mishra, Ravinesh
Parveen, Shama
Ahmed, Niyaz
Pal, Manoj
Kumar, Deepak
author_sort Haneef, Jamshed
collection PubMed
description Liquid chromatography tandem mass chromatography (LC–MS/MS) is an important hyphenated technique for quantitative analysis of drugs in biological fluids. Because of high sensitivity and selectivity, LC–MS/MS has been used for pharmacokinetic studies, metabolites identification in the plasma and urine. This manuscript gives comprehensive analytical review, focusing on chromatographic separation approaches (column packing materials, column length and mobile phase) as well as different acquisition modes (SIM, MRM) for quantitative analysis of glucocorticoids and stimulants. This review is not meant to be exhaustive but rather to provide a general overview for detection and confirmation of target drugs using LC–MS/MS and thus useful in the doping analysis, toxicological studies as well as in pharmaceutical analysis.
format Online
Article
Text
id pubmed-5760999
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Xi'an Jiaotong University
record_format MEDLINE/PubMed
spelling pubmed-57609992018-02-05 Application of LC–MS/MS for quantitative analysis of glucocorticoids and stimulants in biological fluids Haneef, Jamshed Shaharyar, Mohammad Husain, Asif Rashid, Mohd Mishra, Ravinesh Parveen, Shama Ahmed, Niyaz Pal, Manoj Kumar, Deepak J Pharm Anal Review Paper Liquid chromatography tandem mass chromatography (LC–MS/MS) is an important hyphenated technique for quantitative analysis of drugs in biological fluids. Because of high sensitivity and selectivity, LC–MS/MS has been used for pharmacokinetic studies, metabolites identification in the plasma and urine. This manuscript gives comprehensive analytical review, focusing on chromatographic separation approaches (column packing materials, column length and mobile phase) as well as different acquisition modes (SIM, MRM) for quantitative analysis of glucocorticoids and stimulants. This review is not meant to be exhaustive but rather to provide a general overview for detection and confirmation of target drugs using LC–MS/MS and thus useful in the doping analysis, toxicological studies as well as in pharmaceutical analysis. Xi'an Jiaotong University 2013-10 2013-04-02 /pmc/articles/PMC5760999/ /pubmed/29403837 http://dx.doi.org/10.1016/j.jpha.2013.03.005 Text en © 2013 Xi’an Jiaotong University. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Review Paper
Haneef, Jamshed
Shaharyar, Mohammad
Husain, Asif
Rashid, Mohd
Mishra, Ravinesh
Parveen, Shama
Ahmed, Niyaz
Pal, Manoj
Kumar, Deepak
Application of LC–MS/MS for quantitative analysis of glucocorticoids and stimulants in biological fluids
title Application of LC–MS/MS for quantitative analysis of glucocorticoids and stimulants in biological fluids
title_full Application of LC–MS/MS for quantitative analysis of glucocorticoids and stimulants in biological fluids
title_fullStr Application of LC–MS/MS for quantitative analysis of glucocorticoids and stimulants in biological fluids
title_full_unstemmed Application of LC–MS/MS for quantitative analysis of glucocorticoids and stimulants in biological fluids
title_short Application of LC–MS/MS for quantitative analysis of glucocorticoids and stimulants in biological fluids
title_sort application of lc–ms/ms for quantitative analysis of glucocorticoids and stimulants in biological fluids
topic Review Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760999/
https://www.ncbi.nlm.nih.gov/pubmed/29403837
http://dx.doi.org/10.1016/j.jpha.2013.03.005
work_keys_str_mv AT haneefjamshed applicationoflcmsmsforquantitativeanalysisofglucocorticoidsandstimulantsinbiologicalfluids
AT shaharyarmohammad applicationoflcmsmsforquantitativeanalysisofglucocorticoidsandstimulantsinbiologicalfluids
AT husainasif applicationoflcmsmsforquantitativeanalysisofglucocorticoidsandstimulantsinbiologicalfluids
AT rashidmohd applicationoflcmsmsforquantitativeanalysisofglucocorticoidsandstimulantsinbiologicalfluids
AT mishraravinesh applicationoflcmsmsforquantitativeanalysisofglucocorticoidsandstimulantsinbiologicalfluids
AT parveenshama applicationoflcmsmsforquantitativeanalysisofglucocorticoidsandstimulantsinbiologicalfluids
AT ahmedniyaz applicationoflcmsmsforquantitativeanalysisofglucocorticoidsandstimulantsinbiologicalfluids
AT palmanoj applicationoflcmsmsforquantitativeanalysisofglucocorticoidsandstimulantsinbiologicalfluids
AT kumardeepak applicationoflcmsmsforquantitativeanalysisofglucocorticoidsandstimulantsinbiologicalfluids

Ejemplares similares