Pharmacokinetic study of inosiplex tablets in healthy Chinese volunteers by hyphenated HPLC and tandem MS techniques

Inosiplex is a compound formulation composed of inosine and p-acetaminobenzoic acid (PABA) salt of N,N-dimethylamino-2-propanol (DIP). This study was to investigate the clinical plasma pharmacokinetic properties of DIP and PABA after single and multiple oral doses of inosiplex tablets in healthy Chi...

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Detalles Bibliográficos
Autores principales: Chen, Mo, Zhang, Yuan, Que, Xiao-Ting, Ding, Ya, Yang, Lin, Wen, Ai-Dong, Hang, Tai-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761005/
https://www.ncbi.nlm.nih.gov/pubmed/29403844
http://dx.doi.org/10.1016/j.jpha.2013.03.001
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author Chen, Mo
Zhang, Yuan
Que, Xiao-Ting
Ding, Ya
Yang, Lin
Wen, Ai-Dong
Hang, Tai-Jun
author_facet Chen, Mo
Zhang, Yuan
Que, Xiao-Ting
Ding, Ya
Yang, Lin
Wen, Ai-Dong
Hang, Tai-Jun
author_sort Chen, Mo
collection PubMed
description Inosiplex is a compound formulation composed of inosine and p-acetaminobenzoic acid (PABA) salt of N,N-dimethylamino-2-propanol (DIP). This study was to investigate the clinical plasma pharmacokinetic properties of DIP and PABA after single and multiple oral doses of inosiplex tablets in healthy Chinese volunteers. The established LC/MS/MS method for plasma DIP determination had a linear range of 0.02–10 µg/mL, and the HPLC method for plasma PABA determination had a linear range of 0.05–40 µg/mL. Linear pharmacokinetic characteristics were found with single oral doses of 0.5, 1.0 and 2.0 g. No obvious accumulation effects were observed for DIP and PABA.
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spelling pubmed-57610052018-02-05 Pharmacokinetic study of inosiplex tablets in healthy Chinese volunteers by hyphenated HPLC and tandem MS techniques Chen, Mo Zhang, Yuan Que, Xiao-Ting Ding, Ya Yang, Lin Wen, Ai-Dong Hang, Tai-Jun J Pharm Anal Original Article Inosiplex is a compound formulation composed of inosine and p-acetaminobenzoic acid (PABA) salt of N,N-dimethylamino-2-propanol (DIP). This study was to investigate the clinical plasma pharmacokinetic properties of DIP and PABA after single and multiple oral doses of inosiplex tablets in healthy Chinese volunteers. The established LC/MS/MS method for plasma DIP determination had a linear range of 0.02–10 µg/mL, and the HPLC method for plasma PABA determination had a linear range of 0.05–40 µg/mL. Linear pharmacokinetic characteristics were found with single oral doses of 0.5, 1.0 and 2.0 g. No obvious accumulation effects were observed for DIP and PABA. Xi'an Jiaotong University 2013-12 2013-03-20 /pmc/articles/PMC5761005/ /pubmed/29403844 http://dx.doi.org/10.1016/j.jpha.2013.03.001 Text en © 2013 Xi’an Jiaotong University. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Original Article
Chen, Mo
Zhang, Yuan
Que, Xiao-Ting
Ding, Ya
Yang, Lin
Wen, Ai-Dong
Hang, Tai-Jun
Pharmacokinetic study of inosiplex tablets in healthy Chinese volunteers by hyphenated HPLC and tandem MS techniques
title Pharmacokinetic study of inosiplex tablets in healthy Chinese volunteers by hyphenated HPLC and tandem MS techniques
title_full Pharmacokinetic study of inosiplex tablets in healthy Chinese volunteers by hyphenated HPLC and tandem MS techniques
title_fullStr Pharmacokinetic study of inosiplex tablets in healthy Chinese volunteers by hyphenated HPLC and tandem MS techniques
title_full_unstemmed Pharmacokinetic study of inosiplex tablets in healthy Chinese volunteers by hyphenated HPLC and tandem MS techniques
title_short Pharmacokinetic study of inosiplex tablets in healthy Chinese volunteers by hyphenated HPLC and tandem MS techniques
title_sort pharmacokinetic study of inosiplex tablets in healthy chinese volunteers by hyphenated hplc and tandem ms techniques
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761005/
https://www.ncbi.nlm.nih.gov/pubmed/29403844
http://dx.doi.org/10.1016/j.jpha.2013.03.001
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