Metabolic profiling of plasma from cardiac surgical patients concurrently administered with tranexamic acid: DI-SPME–LC–MS analysis

A metabolic profile of plasma samples from patients undergoing heart surgery with the use of cardiopulmonary bypass (CPB) and concurrent administration of tranexamic acid was determined. Direct immersion solid phase microextraction (DI-SPME), a new sampling and sample preparation tool for metabolomi...

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Detalles Bibliográficos
Autores principales: Bojko, Barbara, Wąsowicz, Marcin, Pawliszyn, Janusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761052/
https://www.ncbi.nlm.nih.gov/pubmed/29403864
http://dx.doi.org/10.1016/j.jpha.2013.03.002
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author Bojko, Barbara
Wąsowicz, Marcin
Pawliszyn, Janusz
author_facet Bojko, Barbara
Wąsowicz, Marcin
Pawliszyn, Janusz
author_sort Bojko, Barbara
collection PubMed
description A metabolic profile of plasma samples from patients undergoing heart surgery with the use of cardiopulmonary bypass (CPB) and concurrent administration of tranexamic acid was determined. Direct immersion solid phase microextraction (DI-SPME), a new sampling and sample preparation tool for metabolomics, was used in this study for the first time to investigate clinical samples. The results showed alteration of diverse compounds involved in different biochemical pathways. The most significant contribution in changes induced by surgery and applied pharmacotherapy was noticed in metabolic profile of lysophospholipids, triacylglycerols, mediators of platelet aggregation, and linoleic acid metabolites. Two cases of individual response to treatment were also reported.
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spelling pubmed-57610522018-02-05 Metabolic profiling of plasma from cardiac surgical patients concurrently administered with tranexamic acid: DI-SPME–LC–MS analysis Bojko, Barbara Wąsowicz, Marcin Pawliszyn, Janusz J Pharm Anal Original Article A metabolic profile of plasma samples from patients undergoing heart surgery with the use of cardiopulmonary bypass (CPB) and concurrent administration of tranexamic acid was determined. Direct immersion solid phase microextraction (DI-SPME), a new sampling and sample preparation tool for metabolomics, was used in this study for the first time to investigate clinical samples. The results showed alteration of diverse compounds involved in different biochemical pathways. The most significant contribution in changes induced by surgery and applied pharmacotherapy was noticed in metabolic profile of lysophospholipids, triacylglycerols, mediators of platelet aggregation, and linoleic acid metabolites. Two cases of individual response to treatment were also reported. Xi'an Jiaotong University 2014-02 2013-04-11 /pmc/articles/PMC5761052/ /pubmed/29403864 http://dx.doi.org/10.1016/j.jpha.2013.03.002 Text en © 2013 Xi’an Jiaotong University. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Original Article
Bojko, Barbara
Wąsowicz, Marcin
Pawliszyn, Janusz
Metabolic profiling of plasma from cardiac surgical patients concurrently administered with tranexamic acid: DI-SPME–LC–MS analysis
title Metabolic profiling of plasma from cardiac surgical patients concurrently administered with tranexamic acid: DI-SPME–LC–MS analysis
title_full Metabolic profiling of plasma from cardiac surgical patients concurrently administered with tranexamic acid: DI-SPME–LC–MS analysis
title_fullStr Metabolic profiling of plasma from cardiac surgical patients concurrently administered with tranexamic acid: DI-SPME–LC–MS analysis
title_full_unstemmed Metabolic profiling of plasma from cardiac surgical patients concurrently administered with tranexamic acid: DI-SPME–LC–MS analysis
title_short Metabolic profiling of plasma from cardiac surgical patients concurrently administered with tranexamic acid: DI-SPME–LC–MS analysis
title_sort metabolic profiling of plasma from cardiac surgical patients concurrently administered with tranexamic acid: di-spme–lc–ms analysis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761052/
https://www.ncbi.nlm.nih.gov/pubmed/29403864
http://dx.doi.org/10.1016/j.jpha.2013.03.002
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