Reagent-free determination of amikacin content in amikacin sulfate injections by FTIR derivative spectroscopy in a continuous flow system

The quantitative estimation of amikacin (AMK) in AMK sulfate injection samples is reported using FTIR-derivative spectrometric method in a continuous flow system. Fourier transform of mid-IR spectra were recorded without any sample pretreatment. A good linear calibration (r>0.999, %RSD<2.0) in...

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Autores principales: Ovalles, José F., Gallignani, Máximo, Brunetto, María R., Rondón, Rebeca A., Ayala, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761086/
https://www.ncbi.nlm.nih.gov/pubmed/29403874
http://dx.doi.org/10.1016/j.jpha.2013.08.001
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author Ovalles, José F.
Gallignani, Máximo
Brunetto, María R.
Rondón, Rebeca A.
Ayala, Carlos
author_facet Ovalles, José F.
Gallignani, Máximo
Brunetto, María R.
Rondón, Rebeca A.
Ayala, Carlos
author_sort Ovalles, José F.
collection PubMed
description The quantitative estimation of amikacin (AMK) in AMK sulfate injection samples is reported using FTIR-derivative spectrometric method in a continuous flow system. Fourier transform of mid-IR spectra were recorded without any sample pretreatment. A good linear calibration (r>0.999, %RSD<2.0) in the range of 7.7–77.0 mg/mL was found. The results showed a good correlation with the manufacturer's and overall they all fell within acceptable limits of most pharmacopoeial monographs on AMK sulfate.
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spelling pubmed-57610862018-02-05 Reagent-free determination of amikacin content in amikacin sulfate injections by FTIR derivative spectroscopy in a continuous flow system Ovalles, José F. Gallignani, Máximo Brunetto, María R. Rondón, Rebeca A. Ayala, Carlos J Pharm Anal Original Article The quantitative estimation of amikacin (AMK) in AMK sulfate injection samples is reported using FTIR-derivative spectrometric method in a continuous flow system. Fourier transform of mid-IR spectra were recorded without any sample pretreatment. A good linear calibration (r>0.999, %RSD<2.0) in the range of 7.7–77.0 mg/mL was found. The results showed a good correlation with the manufacturer's and overall they all fell within acceptable limits of most pharmacopoeial monographs on AMK sulfate. Xi'an Jiaotong University 2014-04 2013-08-14 /pmc/articles/PMC5761086/ /pubmed/29403874 http://dx.doi.org/10.1016/j.jpha.2013.08.001 Text en © 2013 Xi’an Jiaotong University. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Original Article
Ovalles, José F.
Gallignani, Máximo
Brunetto, María R.
Rondón, Rebeca A.
Ayala, Carlos
Reagent-free determination of amikacin content in amikacin sulfate injections by FTIR derivative spectroscopy in a continuous flow system
title Reagent-free determination of amikacin content in amikacin sulfate injections by FTIR derivative spectroscopy in a continuous flow system
title_full Reagent-free determination of amikacin content in amikacin sulfate injections by FTIR derivative spectroscopy in a continuous flow system
title_fullStr Reagent-free determination of amikacin content in amikacin sulfate injections by FTIR derivative spectroscopy in a continuous flow system
title_full_unstemmed Reagent-free determination of amikacin content in amikacin sulfate injections by FTIR derivative spectroscopy in a continuous flow system
title_short Reagent-free determination of amikacin content in amikacin sulfate injections by FTIR derivative spectroscopy in a continuous flow system
title_sort reagent-free determination of amikacin content in amikacin sulfate injections by ftir derivative spectroscopy in a continuous flow system
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761086/
https://www.ncbi.nlm.nih.gov/pubmed/29403874
http://dx.doi.org/10.1016/j.jpha.2013.08.001
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