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Homocysteine, folate, hs-C-reactive protein, tumor necrosis factor alpha and inflammatory proteins: are these biomarkers related to nutritional status and cardiovascular risk in childhood-onset systemic lupus erythematosus?

BACKGROUND: Childhood-onset systemic lupus erythematosus (c-SLE) is a chronic autoimmune disease which increases cardiovascular risk factors (CRF) such as elevated homocysteine, TNF-α, and hs-C reactive protein. METHODS: We evaluated BMI, waist circumference (WC), 24-h recalls, SLEDAI-2 K, SLICC/ACR...

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Autores principales: Salomão, Roberta Garcia, de Carvalho, Luciana Martins, Izumi, Clarice, Czernisz, Érika Silva, Rosa, José César, Antonini, Sonir Roberto Rauber, Bueno, Ana Carolina, Almada, Maria Olímpia Ribeiro do Vale, Coelho-Landell, Carolina de Almeida, Jordão, Alceu Afonso, Ferriani, Virgínia Paes Leme, Monteiro, Jacqueline Pontes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761099/
https://www.ncbi.nlm.nih.gov/pubmed/29316941
http://dx.doi.org/10.1186/s12969-017-0220-y
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author Salomão, Roberta Garcia
de Carvalho, Luciana Martins
Izumi, Clarice
Czernisz, Érika Silva
Rosa, José César
Antonini, Sonir Roberto Rauber
Bueno, Ana Carolina
Almada, Maria Olímpia Ribeiro do Vale
Coelho-Landell, Carolina de Almeida
Jordão, Alceu Afonso
Ferriani, Virgínia Paes Leme
Monteiro, Jacqueline Pontes
author_facet Salomão, Roberta Garcia
de Carvalho, Luciana Martins
Izumi, Clarice
Czernisz, Érika Silva
Rosa, José César
Antonini, Sonir Roberto Rauber
Bueno, Ana Carolina
Almada, Maria Olímpia Ribeiro do Vale
Coelho-Landell, Carolina de Almeida
Jordão, Alceu Afonso
Ferriani, Virgínia Paes Leme
Monteiro, Jacqueline Pontes
author_sort Salomão, Roberta Garcia
collection PubMed
description BACKGROUND: Childhood-onset systemic lupus erythematosus (c-SLE) is a chronic autoimmune disease which increases cardiovascular risk factors (CRF) such as elevated homocysteine, TNF-α, and hs-C reactive protein. METHODS: We evaluated BMI, waist circumference (WC), 24-h recalls, SLEDAI-2 K, SLICC/ACR-DI, serum levels of homocysteine, folate, TNF-α, hs-C reactive protein, lipid profile, proteomic data, and duration of corticosteroid therapy in 19 c-SLE and 38 healthy volunteers. Physiological and anthropometric variables of c-SLE and healthy controls were compared by ANCOVA. k-cluster was used to separate c-SLE into two different groups with the best and the worst metabolic profile according to previous analysis showing some metabolites that were statistically different from controls, such as homocysteine, TNF-α, hs-CRP and folate levels. These two clusters were again compared with the control group regarding nutritional parameters, lipid profile and also proteomic data. RESULTS: Individuals with c-SLE presented higher BMI, WC, homocysteine, triglycerides, TNF-α, hs-CRP and lower folate levels when compared to controls. We found 10 proteins whose relative abundances were statistically different between control group and lupus clusters with the best (LCBMP) and the worst metabolic profile (LCWMP). A significant positive correlation was found between TNF-α and triglycerides and between hs-CRP and duration of corticosteroid therapy. CONCLUSION: Cardiovascular disease (CVD) risk parameters were worse in c-SLE. A less protective CVD proteomic profile was found in LCWMP.
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spelling pubmed-57610992018-01-16 Homocysteine, folate, hs-C-reactive protein, tumor necrosis factor alpha and inflammatory proteins: are these biomarkers related to nutritional status and cardiovascular risk in childhood-onset systemic lupus erythematosus? Salomão, Roberta Garcia de Carvalho, Luciana Martins Izumi, Clarice Czernisz, Érika Silva Rosa, José César Antonini, Sonir Roberto Rauber Bueno, Ana Carolina Almada, Maria Olímpia Ribeiro do Vale Coelho-Landell, Carolina de Almeida Jordão, Alceu Afonso Ferriani, Virgínia Paes Leme Monteiro, Jacqueline Pontes Pediatr Rheumatol Online J Research Article BACKGROUND: Childhood-onset systemic lupus erythematosus (c-SLE) is a chronic autoimmune disease which increases cardiovascular risk factors (CRF) such as elevated homocysteine, TNF-α, and hs-C reactive protein. METHODS: We evaluated BMI, waist circumference (WC), 24-h recalls, SLEDAI-2 K, SLICC/ACR-DI, serum levels of homocysteine, folate, TNF-α, hs-C reactive protein, lipid profile, proteomic data, and duration of corticosteroid therapy in 19 c-SLE and 38 healthy volunteers. Physiological and anthropometric variables of c-SLE and healthy controls were compared by ANCOVA. k-cluster was used to separate c-SLE into two different groups with the best and the worst metabolic profile according to previous analysis showing some metabolites that were statistically different from controls, such as homocysteine, TNF-α, hs-CRP and folate levels. These two clusters were again compared with the control group regarding nutritional parameters, lipid profile and also proteomic data. RESULTS: Individuals with c-SLE presented higher BMI, WC, homocysteine, triglycerides, TNF-α, hs-CRP and lower folate levels when compared to controls. We found 10 proteins whose relative abundances were statistically different between control group and lupus clusters with the best (LCBMP) and the worst metabolic profile (LCWMP). A significant positive correlation was found between TNF-α and triglycerides and between hs-CRP and duration of corticosteroid therapy. CONCLUSION: Cardiovascular disease (CVD) risk parameters were worse in c-SLE. A less protective CVD proteomic profile was found in LCWMP. BioMed Central 2018-01-09 /pmc/articles/PMC5761099/ /pubmed/29316941 http://dx.doi.org/10.1186/s12969-017-0220-y Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Salomão, Roberta Garcia
de Carvalho, Luciana Martins
Izumi, Clarice
Czernisz, Érika Silva
Rosa, José César
Antonini, Sonir Roberto Rauber
Bueno, Ana Carolina
Almada, Maria Olímpia Ribeiro do Vale
Coelho-Landell, Carolina de Almeida
Jordão, Alceu Afonso
Ferriani, Virgínia Paes Leme
Monteiro, Jacqueline Pontes
Homocysteine, folate, hs-C-reactive protein, tumor necrosis factor alpha and inflammatory proteins: are these biomarkers related to nutritional status and cardiovascular risk in childhood-onset systemic lupus erythematosus?
title Homocysteine, folate, hs-C-reactive protein, tumor necrosis factor alpha and inflammatory proteins: are these biomarkers related to nutritional status and cardiovascular risk in childhood-onset systemic lupus erythematosus?
title_full Homocysteine, folate, hs-C-reactive protein, tumor necrosis factor alpha and inflammatory proteins: are these biomarkers related to nutritional status and cardiovascular risk in childhood-onset systemic lupus erythematosus?
title_fullStr Homocysteine, folate, hs-C-reactive protein, tumor necrosis factor alpha and inflammatory proteins: are these biomarkers related to nutritional status and cardiovascular risk in childhood-onset systemic lupus erythematosus?
title_full_unstemmed Homocysteine, folate, hs-C-reactive protein, tumor necrosis factor alpha and inflammatory proteins: are these biomarkers related to nutritional status and cardiovascular risk in childhood-onset systemic lupus erythematosus?
title_short Homocysteine, folate, hs-C-reactive protein, tumor necrosis factor alpha and inflammatory proteins: are these biomarkers related to nutritional status and cardiovascular risk in childhood-onset systemic lupus erythematosus?
title_sort homocysteine, folate, hs-c-reactive protein, tumor necrosis factor alpha and inflammatory proteins: are these biomarkers related to nutritional status and cardiovascular risk in childhood-onset systemic lupus erythematosus?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761099/
https://www.ncbi.nlm.nih.gov/pubmed/29316941
http://dx.doi.org/10.1186/s12969-017-0220-y
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