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Elevated brain natriuretic peptide levels in chronic fatigue syndrome associate with cardiac dysfunction: a case control study
OBJECTIVES: To explore levels of the brain natriuretic peptide (BNP) and how these associate with the cardiac abnormalities recently identified in chronic fatigue syndrome (CFS). METHODS: Cardiac magnetic resonance examinations were performed using 3T Philips Intera Achieva scanner (Best, Netherland...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761285/ https://www.ncbi.nlm.nih.gov/pubmed/29344367 http://dx.doi.org/10.1136/openhrt-2017-000697 |
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author | Tomas, Cara Finkelmeyer, Andreas Hodgson, Tim MacLachlan, Laura MacGowan, Guy A Blamire, Andrew M Newton, Julia L |
author_facet | Tomas, Cara Finkelmeyer, Andreas Hodgson, Tim MacLachlan, Laura MacGowan, Guy A Blamire, Andrew M Newton, Julia L |
author_sort | Tomas, Cara |
collection | PubMed |
description | OBJECTIVES: To explore levels of the brain natriuretic peptide (BNP) and how these associate with the cardiac abnormalities recently identified in chronic fatigue syndrome (CFS). METHODS: Cardiac magnetic resonance examinations were performed using 3T Philips Intera Achieva scanner (Best, Netherlands) in CFS (Fukuda) participants and sedentary controls matched group wise for age and sex. BNP was also measured by using an enzyme immunoassay in plasma from 42 patients with CFS and 10 controls. RESULTS: BNP levels were significantly higher in the CFS cohort compared with the matched controls (P=0.013). When we compared cardiac volumes (end-diastolic and end-systolic) between those with high BNP levels (BNP >400 pg/mL) and low BNP (<400 pg/mL), there were significantly lower cardiac volumes in those with the higher BNP levels in both end-systolic and end-diastolic volumes (P=0.05). There were no relationships between fatigue severity, length of disease and BNP levels (P=0.2) suggesting that our findings are unlikely to be related to deconditioning. CONCLUSION: This study confirms an association between reduced cardiac volumes and BNP in CFS. Lack of relationship between length of disease suggests that findings are not secondary to deconditioning. Further studies are needed to explore the utility of BNP to act as a stratification paradigm in CFS that directs targeted treatments. TRAIL REGISTRATION NUMBER: Registered with NIHR Portfolio CLRN ID 97805. |
format | Online Article Text |
id | pubmed-5761285 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-57612852018-01-17 Elevated brain natriuretic peptide levels in chronic fatigue syndrome associate with cardiac dysfunction: a case control study Tomas, Cara Finkelmeyer, Andreas Hodgson, Tim MacLachlan, Laura MacGowan, Guy A Blamire, Andrew M Newton, Julia L Open Heart Special Populations OBJECTIVES: To explore levels of the brain natriuretic peptide (BNP) and how these associate with the cardiac abnormalities recently identified in chronic fatigue syndrome (CFS). METHODS: Cardiac magnetic resonance examinations were performed using 3T Philips Intera Achieva scanner (Best, Netherlands) in CFS (Fukuda) participants and sedentary controls matched group wise for age and sex. BNP was also measured by using an enzyme immunoassay in plasma from 42 patients with CFS and 10 controls. RESULTS: BNP levels were significantly higher in the CFS cohort compared with the matched controls (P=0.013). When we compared cardiac volumes (end-diastolic and end-systolic) between those with high BNP levels (BNP >400 pg/mL) and low BNP (<400 pg/mL), there were significantly lower cardiac volumes in those with the higher BNP levels in both end-systolic and end-diastolic volumes (P=0.05). There were no relationships between fatigue severity, length of disease and BNP levels (P=0.2) suggesting that our findings are unlikely to be related to deconditioning. CONCLUSION: This study confirms an association between reduced cardiac volumes and BNP in CFS. Lack of relationship between length of disease suggests that findings are not secondary to deconditioning. Further studies are needed to explore the utility of BNP to act as a stratification paradigm in CFS that directs targeted treatments. TRAIL REGISTRATION NUMBER: Registered with NIHR Portfolio CLRN ID 97805. BMJ Publishing Group 2017-12-27 /pmc/articles/PMC5761285/ /pubmed/29344367 http://dx.doi.org/10.1136/openhrt-2017-000697 Text en © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Special Populations Tomas, Cara Finkelmeyer, Andreas Hodgson, Tim MacLachlan, Laura MacGowan, Guy A Blamire, Andrew M Newton, Julia L Elevated brain natriuretic peptide levels in chronic fatigue syndrome associate with cardiac dysfunction: a case control study |
title | Elevated brain natriuretic peptide levels in chronic fatigue syndrome associate with cardiac dysfunction: a case control study |
title_full | Elevated brain natriuretic peptide levels in chronic fatigue syndrome associate with cardiac dysfunction: a case control study |
title_fullStr | Elevated brain natriuretic peptide levels in chronic fatigue syndrome associate with cardiac dysfunction: a case control study |
title_full_unstemmed | Elevated brain natriuretic peptide levels in chronic fatigue syndrome associate with cardiac dysfunction: a case control study |
title_short | Elevated brain natriuretic peptide levels in chronic fatigue syndrome associate with cardiac dysfunction: a case control study |
title_sort | elevated brain natriuretic peptide levels in chronic fatigue syndrome associate with cardiac dysfunction: a case control study |
topic | Special Populations |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761285/ https://www.ncbi.nlm.nih.gov/pubmed/29344367 http://dx.doi.org/10.1136/openhrt-2017-000697 |
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